College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, PuZhuNanLu No.30, Nanjing 211816, Jiangsu Province, China.
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, PuZhuNanLu No.30, Nanjing 211816, Jiangsu Province, China.
Int J Pharm. 2024 Dec 25;667(Pt A):124867. doi: 10.1016/j.ijpharm.2024.124867. Epub 2024 Oct 24.
Ideal drug delivery system is designed to accurately deliver the drug to its intended site. The development of conjugate drug delivery system introduces a novel pathway to precise drug delivery with advantages over traditional methods. The core of a conjugate drug delivery system comprises a molecule with two functional components, bounded by a linker structure. One component is responsible for delivering or stabilizing the conjugate, while the other is used to provide the therapeutic or diagnostic effects of the bioactivity. Conjugate drug delivery system improves patient health by maintaining the structural stability of drugs in molecular form, delivering therapeutics or diagnostic material to the target site, minimising off-target accumulation and promoting patient compliance. This system includes various types of drug conjugates that modulate drug pharmacokinetics, stability, absorption, and exposure in lesions and healthy tissues. In this review, we focus on the key characteristics and recent advances of various conjugate drug delivery systems and explore their mechanisms. We also point out the current challenges faced by conjugate drug delivery system and look forward to the future prospects.
理想的药物传递系统旨在将药物精确递送到其预期的部位。结合药物传递系统的发展为精确药物传递引入了一种新途径，其具有优于传统方法的优势。结合药物传递系统的核心由两个功能组件的分子组成，通过连接体结构连接。一个组件负责传递或稳定结合物，而另一个组件用于提供生物活性的治疗或诊断效果。结合药物传递系统通过保持药物在分子形式下的结构稳定性，将治疗剂或诊断材料递送到靶位，减少非靶位的积累，提高患者的顺应性，从而改善患者的健康状况。该系统包括各种类型的药物结合物，可调节药物的药代动力学、稳定性、吸收和在病变和健康组织中的暴露。在这篇综述中，我们重点介绍了各种结合药物传递系统的关键特征和最新进展，并探讨了它们的作用机制。我们还指出了结合药物传递系统目前面临的挑战，并展望了未来的前景。
