表观遗传学与表观基因组学之间的区别。
The distinction between epigenetics and epigenomics.
作者信息
Struhl Kevin
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Genet. 2024 Dec;40(12):995-997. doi: 10.1016/j.tig.2024.10.002. Epub 2024 Oct 24.
Abstract
'Epigenetics' is the process by which distinct cell types or cell states are inherited through multiple cell divisions. 'Epigenomics' refers to DNA-associated physical and functional entities including histone modifications and DNA methylation, not concepts of inheritance. Conflating epigenetics and epigenomics is confusing and causes misunderstanding of a fundamental biological process.
摘要
“表观遗传学”是指不同细胞类型或细胞状态通过多次细胞分裂得以遗传的过程。“表观基因组学”指的是与DNA相关的物理和功能实体，包括组蛋白修饰和DNA甲基化，而非遗传概念。将表观遗传学和表观基因组学混为一谈会造成混淆，并导致对一个基本生物学过程的误解。
相似文献
1
The distinction between epigenetics and epigenomics.表观遗传学与表观基因组学之间的区别。
Trends Genet. 2024 Dec;40(12):995-997. doi: 10.1016/j.tig.2024.10.002. Epub 2024 Oct 24.
2
Epigenomics in stress tolerance of plants under the climate change.植物在气候变化下的应激耐受中的表观基因组学。
Mol Biol Rep. 2023 Jul;50(7):6201-6216. doi: 10.1007/s11033-023-08539-6. Epub 2023 Jun 9.
3
Epitranscriptomics and epigenetics: two sides of the same coin?转录组学和表观遗传学：同一枚硬币的两面？
Clin Epigenetics. 2024 Sep 3;16(1):121. doi: 10.1186/s13148-024-01729-4.
4
Investigation of epigenetics in kidney cell biology.肾细胞生物学中的表观遗传学研究。
Methods Cell Biol. 2019;153:255-278. doi: 10.1016/bs.mcb.2019.04.015. Epub 2019 Jun 13.
5
Laboratory methods to decipher epigenetic signatures: a comparative review.解析表观遗传特征的实验室方法：比较综述。
Cell Mol Biol Lett. 2021 Nov 11;26(1):46. doi: 10.1186/s11658-021-00290-9.
6
Epigenetics in cancer development, diagnosis and therapy.癌症发生、诊断与治疗中的表观遗传学
Prog Mol Biol Transl Sci. 2023;198:73-92. doi: 10.1016/bs.pmbts.2023.01.009. Epub 2023 Feb 24.
7
55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.第 55 届加拿大分子生物科学学会表观遗传学和基因组稳定性年会。2012 年 3 月 14 日至 18 日，加拿大不列颠哥伦比亚省惠斯勒。
Epigenomics. 2012 Jun;4(3):255-9. doi: 10.2217/epi.12.26.
8
Epigenomics, Pharmacoepigenomics, and Personalized Medicine in Cervical Cancer.宫颈癌中的表观基因组学、药物表观基因组学与个性化医疗
Public Health Genomics. 2017;20(2):100-115. doi: 10.1159/000475804. Epub 2017 May 19.
9
Next generation sequencing in epigenetics: insights and challenges.下一代测序在表观遗传学中的应用：研究进展与挑战。
Semin Cell Dev Biol. 2012 Apr;23(2):192-9. doi: 10.1016/j.semcdb.2011.10.010. Epub 2011 Oct 19.
10
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes.dbHiMo：一个用于组蛋白修饰酶的基于网络的表观基因组学平台。
Database (Oxford). 2015 Jun 8;2015:bav052. doi: 10.1093/database/bav052. Print 2015.
引用本文的文献
1
Current Bioinformatics Tools in Precision Oncology.精准肿瘤学中的当前生物信息学工具
MedComm (2020). 2025 Jul 9;6(7):e70243. doi: 10.1002/mco2.70243. eCollection 2025 Jul.
2
RNA-Mediated Non-Mendelian Inheritance in Mice: The Power of Memory.小鼠中RNA介导的非孟德尔遗传：记忆的力量。
Biomolecules. 2025 Apr 21;15(4):605. doi: 10.3390/biom15040605.
3
Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications.连接表观基因组学与肿瘤免疫代谢：分子机制及治疗意义
Mol Cancer. 2025 Mar 8;24(1):71. doi: 10.1186/s12943-025-02269-y.
4
Stage-specific DNA methylation dynamics in mammalian heart development.哺乳动物心脏发育过程中特定阶段的DNA甲基化动态变化
Epigenomics. 2025 Apr;17(5):359-371. doi: 10.1080/17501911.2025.2467024. Epub 2025 Feb 21.
本文引用的文献
1
The molecular basis of heterochromatin assembly and epigenetic inheritance.异染色质组装和表观遗传遗传的分子基础。
Mol Cell. 2023 Jun 1;83(11):1767-1785. doi: 10.1016/j.molcel.2023.04.020. Epub 2023 May 18.
2
The molecular principles of gene regulation by Polycomb repressive complexes.多梳抑制复合物调控基因表达的分子机制。
Nat Rev Mol Cell Biol. 2021 Dec;22(12):815-833. doi: 10.1038/s41580-021-00398-y. Epub 2021 Aug 16.
3
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.由 RNAi 和组蛋白 H3K9 甲基化偶联介导的表观遗传遗传。
Nature. 2018 Jun;558(7711):615-619. doi: 10.1038/s41586-018-0239-3. Epub 2018 Jun 20.
4
SIR proteins and the assembly of silent chromatin in budding yeast.SIR 蛋白与芽殖酵母中沉默染色质的组装。
Annu Rev Genet. 2013;47:275-306. doi: 10.1146/annurev-genet-021313-173730. Epub 2013 Sep 4.
5
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.利用合成修饰 mRNA 高效重编程人类细胞为多能性干细胞并进行定向分化。
Cell Stem Cell. 2010 Nov 5;7(5):618-30. doi: 10.1016/j.stem.2010.08.012. Epub 2010 Sep 30.
6
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.一种涉及核因子-κB、Lin28、Let-7微小RNA和白细胞介素6的表观遗传开关将炎症与细胞转化联系起来。
Cell. 2009 Nov 13;139(4):693-706. doi: 10.1016/j.cell.2009.10.014. Epub 2009 Oct 29.
7
Generation of induced pluripotent stem cells using recombinant proteins.利用重组蛋白生成诱导多能干细胞。
Cell Stem Cell. 2009 May 8;4(5):381-4. doi: 10.1016/j.stem.2009.04.005. Epub 2009 Apr 23.
8
An elaborate pathway required for Ras-mediated epigenetic silencing.Ras介导的表观遗传沉默所需的复杂途径。
Nature. 2007 Oct 25;449(7165):1073-7. doi: 10.1038/nature06251.
9
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.通过特定因子从小鼠胚胎和成体成纤维细胞培养物中诱导多能干细胞。
Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10.
10
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.延伸中的RNA聚合酶II对Set1组蛋白甲基转移酶的靶向募集为近期转录活性提供了一个局部标记和记忆。
Mol Cell. 2003 Mar;11(3):709-19. doi: 10.1016/s1097-2765(03)00092-3.
Zotero 插件