Host-guest-induced electronic state triggers two-electron oxygen reduction electrocatalysis.

Supramolecular polymers possess great potential in catalysis owing to their distinctive molecular recognition and dynamic crosslinking features. However, investigating supramolecular electrocatalysts with high efficiency in oxygen reduction reaction to hydrogen peroxide (ORHP) remains an unexplored frontier. Herein, we present organic polymers for ORHP by introducing cyclodextrin-containing noncovalent building blocks, affording these supramolecules with abundant dynamic bonds. The electronic states and reaction kinetics are further well-modulated via a host-guest strategy, resulting in appropriate regional electron binding force and controllable chemical activity. Notably, integrating supramolecular units into phenyl group-containing model covalent polymer achieves a production rate of 9.14 mol g h, with 98.01% Faraday efficiency, surpassing most reported metal-free electrocatalysts. Moreover, the dynamic bonds in supramolecular catalysts can effectively regulate the binding ability of oxygen intermediates, leading to high reactivity and selectivity for the 2e pathway. Supported by theory calculation and in situ experiment, C atoms (site-1) adjacent to the -C = N (N) group are potential active sites. This work pioneers host-guest strategy and provides inspiring ideas for the ORHP process.