Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, China.
Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, Hunan Province, China.
Sci Rep. 2024 Oct 25;14(1):25331. doi: 10.1038/s41598-024-76798-9.
Accumulating research showed that ENC1 plays a critical role in maintaining the physiological functions. However, little is known about its role in predicting prognosis and immunotherapy response across cancers. In our results, compared to normal tissues, most cancer tissues exhibit increased ENC1 expression. We found that the most common type of genetic variation was gene mutation. In addition, a positive correlation was found between CNV and ENC1 expression. Moreover, the overexpression of ENC1 was positively correlated with poor clinical outcomes. The GSEA results showed that ENC1 is closely correlated with tumor-promoting biological functions in most cancers. ENC1 is also closely negatively associated with the infiltration levels of T cells, activated NK cells, and B cells. Most immunomodulators are positively associated with ENC1. Further, we verified that inhibition of ENC1 expression suppressed the proliferation and migration of breast cancer, pancreatic cancer and glioma cells. In conclusion, our study demonstrated that ENC1 plays a protumorigenic role in most cancers. Additionally, ENC1 is closely correlated with tumor microenvironment features and immune checkpoint inhibitors expression. Overall, ENC1 could serve as a promising potential prognostic biomarker in various tumors.
越来越多的研究表明，ENC1 在维持生理功能方面起着关键作用。然而，关于其在预测癌症预后和免疫治疗反应中的作用知之甚少。在我们的研究结果中，与正常组织相比，大多数癌症组织表现出 ENC1 表达增加。我们发现最常见的遗传变异类型是基因突变。此外，还发现 CNV 与 ENC1 表达之间存在正相关。此外，ENC1 的过表达与不良临床结局呈正相关。GSEA 结果表明，ENC1 与大多数癌症中促进肿瘤的生物学功能密切相关。ENC1 也与 T 细胞、活化 NK 细胞和 B 细胞的浸润水平密切负相关。大多数免疫调节剂与 ENC1 呈正相关。此外，我们验证了抑制 ENC1 的表达可抑制乳腺癌、胰腺癌和神经胶质瘤细胞的增殖和迁移。总之，我们的研究表明，ENC1 在大多数癌症中起致癌作用。此外，ENC1 与肿瘤微环境特征和免疫检查点抑制剂表达密切相关。总的来说，ENC1 可以作为各种肿瘤有前途的潜在预后生物标志物。
