Gynecology Oncology Department, Faculty of Medicine, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC Cancer. 2024 Oct 25;24(1):1318. doi: 10.1186/s12885-024-13069-w.
Ovarian granulosa cell tumor (OGCT) is a rare female pathology with few available demographic data. Besides, there are no comprehensive clinical characteristics regarding the OGCT in Iran. Thus, this study aimed to assess the clinical features and survival rate of OGCT patients in Iran to expand the scope of knowledge in this field.
In this 10-year retrospective study (2013-2023), the cases were gathered from the oncologic clinic of women (Imam Khomeini Hospital, Tehran, Iran). The patients with definite OGCT diagnosis were selected based on the inclusion and exclusion criteria including medical history, interfering backgrounds, demographic data, histopathological assessment, clinical and para-clinical features, survival rates, and all previous medical reports for definite diagnosis of OGCT along with approved pathology samples.
The median age and BMI values of Iranian patients were 45 (19 ~ 83) years and 28.04 (19.4 ~ 48.0), respectively. The most common symptom was abdominal pain (56%) and 69.2% of cases were menopause. In 81.3% of cases, ovarian tumors were detected and metastasis was rare. Most patients (40.6%) underwent total abdominal hysterectomy and OGCT relapsing cases were seen in 13.2% of patients. The median of overall survival (OS) value using the Kaplan-Meier estimate was 52 months (95%CI:37.47-66.53), and the median of disease-free survival (DFS) was 45 months (95%CI: 28.88-61.12). There was a significant (p < 0.05) relation between chemotherapy and left oophorectomy with OS. A significant (p < 0.05) correlation was also detected among the OGCT stage and left oophorectomy with DFS.
OS and DFS values showed that the OGCT in Iranian patients can be treated in most cases using two main procedures of chemotherapy and oophorectomy. Parallel application of both procedures and associated outcomes are suggested for future studies.
卵巢颗粒细胞瘤（OGCT）是一种罕见的女性病理学疾病，可用的人口统计学数据较少。此外，伊朗尚无关于 OGCT 的全面临床特征。因此，本研究旨在评估伊朗 OGCT 患者的临床特征和生存率，以扩展该领域的知识范围。
在这项为期 10 年的回顾性研究（2013-2023 年）中，病例是从伊朗德黑兰妇女肿瘤诊所（Imam Khomeini 医院）收集的。根据纳入和排除标准，选择具有明确 OGCT 诊断的患者，纳入标准包括病史、干扰背景、人口统计学数据、组织病理学评估、临床和辅助临床特征、生存率以及所有以前的用于明确 OGCT 诊断的医疗报告以及经批准的病理样本。
伊朗患者的中位年龄和 BMI 值分别为 45（1983）岁和 28.04（19.448.0）。最常见的症状是腹痛（56%），69.2%的病例处于绝经后状态。81.3%的病例中检测到卵巢肿瘤，转移罕见。大多数患者（40.6%）接受了全子宫切除术，13.2%的患者出现 OGCT 复发。使用 Kaplan-Meier 估计的总生存率（OS）中位数为 52 个月（95%CI：37.47-66.53），无病生存率（DFS）中位数为 45 个月（95%CI：28.88-61.12）。化疗和左侧卵巢切除术与 OS 之间存在显著（p<0.05）关系。OGCT 分期和左侧卵巢切除术与 DFS 之间也存在显著（p<0.05）相关性。
OS 和 DFS 值表明，伊朗患者的 OGCT 可以通过化疗和卵巢切除术这两种主要手术来治疗。建议在未来的研究中同时应用这两种方法及其相关结果。
