Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box: 14155/61170, Tehran, Iran.
BMC Endocr Disord. 2024 Oct 25;24(1):226. doi: 10.1186/s12902-024-01734-x.
Research on the relationship between dietary phytochemical intake and the anthropometric indices as well as the diabetic foot ulcers (DFUs) remains inconsistent. We aimed to investigate the associations of dietary phytochemical index (DPI) with the novel anthropometric indices and the severity of DFUs.
This cross-sectional study was conducted on 339 adults with type 2 diabetes. Dietary intake was assessed using three 24-hour dietary recalls. To quantify the phytochemical content of the diet, the DPI estimation was done through an equation proposed by McCarty. The International Working Group on the Diabetic Foot (IWGDF) criteria and Wagner classification system were applied to assess DFUs. New anthropometric indices including a body shape index (ABSI), body roundness index (BRI) and abdominal volume index (AVI) were calculated based on formulas. We employed analysis of variance (ANOVA), analysis of covariance (ANCOVA) and logistic regression to explore associations between DPI and the anthropometric indices and DFU variables.
Our results revealed no significant association between DPI and the foot ulcer indices, following adjusting for the possible covariates. Furthermore, we also examined the relationship between diabetic neuropathy, as measured by monofilament score, and the DPI. Similarly, we did not find any substantial relationship between the DPI and monofilament score (OR: 1.18; 95% CI: 0.66-2.09; P = 0.56), as well as biochemical indices. Our analysis did not reveal any significant associations between the DPI and ABSI (OR: 0.70; 95% CI: 0.35-1.38; P = 0.30), BRI (OR: 0.80; 95% CI: 0.33-1.95; P = 0.59), and AVI (OR: 1.99; 95% CI: 0.92-4.33; P = 0.08).
Our study revealed no significant links between the DPI and foot ulcer indices, neuropathy measures, and anthropometric indices. These findings imply that factors beyond dietary phytochemical intake may exert greater influence on the development of foot ulcers in diabetes.
关于饮食植物化学物质摄入与人体测量指数以及糖尿病足溃疡（DFUs）之间的关系的研究结果仍不一致。我们旨在研究饮食植物化学物质指数（DPI）与新型人体测量指数和 DFUs 严重程度之间的关系。
本横断面研究纳入了 339 名 2 型糖尿病成人。通过 3 次 24 小时膳食回忆来评估膳食摄入。为了量化饮食中的植物化学物质含量，通过 McCarty 提出的方程进行 DPI 估算。应用国际糖尿病足工作组（IWGDF）标准和 Wagner 分类系统评估 DFUs。根据公式计算新型人体测量指数，包括体型指数（ABSI）、体圆度指数（BRI）和腹部容量指数（AVI）。采用方差分析（ANOVA）、协方差分析（ANCOVA）和逻辑回归来探讨 DPI 与人体测量指数和 DFU 变量之间的关系。
在调整了可能的混杂因素后，我们的结果显示 DPI 与足部溃疡指数之间无显著关联。此外，我们还检查了用单丝评分衡量的糖尿病神经病变与 DPI 之间的关系。同样，我们也没有发现 DPI 与单丝评分（OR：1.18；95%CI：0.66-2.09；P=0.56）以及生化指标之间存在显著关系。我们的分析也没有显示 DPI 与 ABSI（OR：0.70；95%CI：0.35-1.38；P=0.30）、BRI（OR：0.80；95%CI：0.33-1.95；P=0.59）和 AVI（OR：1.99；95%CI：0.92-4.33；P=0.08）之间存在显著关联。
我们的研究显示 DPI 与足部溃疡指数、神经病变测量值和人体测量指数之间没有显著联系。这些发现表明，可能有饮食以外的其他因素对糖尿病患者足部溃疡的发生有更大的影响。
