Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Endocrinology and Metabolism, De Boelelaan 1117, Amsterdam, The Netherlands.
Amsterdam Movement Sciences, Tissue Function and Regeneration, Amsterdam, The Netherlands.
Biomolecules. 2024 Oct 10;14(10):1276. doi: 10.3390/biom14101276.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [F]NaF PET/CT imaging in FOP as a monitoring modality.
进行性骨化性纤维发育不良（FOP）是一种罕见的遗传性骨疾病，其特征是结缔组织间歇性发作，随后常伴有异位骨形成。由于缺乏用于发作或异位骨形成的可用血浆可溶性生物标志物，因此对疾病活动的监测存在严重挑战，无法测量或预测疾病进展。最近，18-氟-氟化钠正电子发射断层扫描/计算机断层扫描([F]NaF PET/CT) 被引入作为骨化性 FOP 活性的潜在标志物。本文综述了[F]NaF 的药代动力学与 FOP 的病理生理学之间的关系，及其在各种与骨骼相关的疾病中作为局部骨骼代谢标志物的用途。此外，该综述特别讨论了[F]NaF PET/CT 成像在 FOP 中的监测作用。
