Geer P G, Wang B C, Goetz K L
Proc Soc Exp Biol Med. 1986 Jan;181(1):33-40. doi: 10.3181/00379727-181-42221.
Although blood pressure rises markedly after acute sinoaortic denervation, animals with chronic sinoaortic denervation have normal or only slightly elevated mean arterial pressures. The present study was performed to determine whether reflexes from cardiac receptors exert antihypertensive effects and thereby lower blood pressure in animals with chronic sinoaortic denervation. We made multiple measurements of blood pressures in dogs with chronic sinoaortic denervation before and after their hearts were denervated surgically. Mean arterial pressure after cardiac denervation (100.3 +/- 4.2 mm Hg) was not significantly different from the mean pressures recorded before cardiac denervation in these sinoaortic-denervated dogs (104.8 +/- 3.1 mm Hg). Also, mean heart rate after cardiac denervation (107.4 +/- 5.5 beats/min) did not differ significantly from the mean heart rate recorded before cardiac denervation (107.2 +/- 5.9 beats/min). Cardiac denervation did, however, appear to reduce the lability of both blood pressure and heart rate in sinoaortic-denervated dogs. We conclude that cardiac receptors are not responsible for maintaining arterial pressure within essentially normal limits in animals with chronic sinoaortic denervation.
虽然急性去窦主动脉神经支配后血压会显著升高，但慢性去窦主动脉神经支配的动物平均动脉压正常或仅略有升高。本研究旨在确定心脏感受器的反射是否具有降压作用，从而降低慢性去窦主动脉神经支配动物的血压。我们对慢性去窦主动脉神经支配的犬在心脏手术去神经支配前后进行了多次血压测量。这些去窦主动脉神经支配犬心脏去神经支配后的平均动脉压（100.3±4.2mmHg）与心脏去神经支配前记录的平均动脉压（104.8±3.1mmHg）无显著差异。此外，心脏去神经支配后的平均心率（107.4±5.5次/分钟）与心脏去神经支配前记录的平均心率（107.2±5.9次/分钟）也无显著差异。然而，心脏去神经支配似乎确实降低了去窦主动脉神经支配犬血压和心率的不稳定性。我们得出结论，在慢性去窦主动脉神经支配的动物中，心脏感受器并非维持动脉压在基本正常范围内的原因。
