低强度微波辐射可减轻吗啡依赖大鼠的纳洛酮诱发戒断综合征。
Low-level microwave irradiation attenuates naloxone-induced withdrawal syndrome in morphine-dependent rats.
作者信息
Lai H, Horita A, Chou C K, Guy A W
出版信息
Pharmacol Biochem Behav. 1986 Jan;24(1):151-3. doi: 10.1016/0091-3057(86)90060-2.
The effect of microwave irradiation on naloxone-induced withdrawal syndrome was studied in rats made morphine dependent by subcutaneous implantation of morphine pellets. Morphine-dependent rats were either exposed to pulsed low-level microwaves (2450 MHz, 1 mW/cm2, 500 pps, 2 musec pulses) or sham-irradiated for 45 min before the naloxone injection. We found that microwave-exposed rats showed significantly less weg-dog-shakes and had higher body temperature than the sham-exposed animals during withdrawal. There was no significant difference in the incident of diarrhea between the two groups of animals. These data further support the results of our previous research suggesting that pulsed low-level microwave irradiation activates endogenous opioids in the rat.
通过皮下植入吗啡丸使大鼠产生吗啡依赖，在此基础上研究了微波辐射对纳洛酮诱发的戒断综合征的影响。在注射纳洛酮前，将吗啡依赖大鼠暴露于脉冲低强度微波（2450兆赫，1毫瓦/平方厘米，500次/秒，2微秒脉冲）下或进行假照射45分钟。我们发现，在戒断期间，暴露于微波的大鼠出现的湿狗样颤抖明显少于假照射动物，且体温更高。两组动物腹泻发生率无显著差异。这些数据进一步支持了我们先前的研究结果，表明脉冲低强度微波辐射可激活大鼠体内的内源性阿片类物质。
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