Ilic Irena, Babic Goran, Dimitrijevic Aleksandra, Sipetic Grujicic Sandra, Jakovljevic Vladimir, Ilic Milena
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Department of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Cancers (Basel). 2024 Oct 20;16(20):3541. doi: 10.3390/cancers16203541.
: This study aimed to evaluate psychosocial burden and its associated factors in women who were referred for additional diagnostic procedures following receipt of a positive cervical-cancer-screening smear result. : A cross-sectional study was performed in a consecutive cohort of only women who received an abnormal Papanicolaou screening result and therefore presented to a gynecologist for additional diagnostic examinations (colposcopy/biopsy/endocervical curettage) at the Clinic for Gynecology and Obstetrics of the Clinical Center. Multivariate linear regression was used for data analysis, with Bonferroni correction applied for multiple comparisons. : Significant independent predictors for the occurrence of psychosocial burden-worry in women with a positive Papanicolaou screening test before diagnostic procedures were the use of oral contraceptives (β = -0.174, < 0.001), alcohol consumption (β = 0.188, < 0.001), anxiety (β = -0.189, = 0.001), high burden of depressive symptoms (β = 0.191, = 0.001) and insufficient knowledge of the meaning of the term dysplasia/precancerous (β = -0.187, < 0.001), according to the multivariate linear regression. The significant independent predictor for the occurrence of psychosocial burden-satisfaction with information/support in women with a positive Papanicolaou screening test before diagnostic procedures was psychological distress (β = -0.210, = 0.001). : Providing information in order to improve understanding of the term dysplasia/precancerous, as well as identifying which women are at risk of psychosocial burden, may help protect against this potential harm among women who receive a positive cervical-cancer-screening result and may facilitate their intention to undergo further diagnostic procedures.
本研究旨在评估在收到宫颈癌筛查涂片结果呈阳性后被转诊进行额外诊断程序的女性的心理社会负担及其相关因素。在临床中心妇产科诊所，对仅接受巴氏涂片检查结果异常并因此向妇科医生进行额外诊断检查（阴道镜检查/活检/宫颈管刮术）的连续女性队列进行了一项横断面研究。采用多元线性回归进行数据分析，并应用Bonferroni校正进行多重比较。根据多元线性回归，在诊断程序前巴氏涂片检查结果呈阳性的女性中，心理社会负担——担忧发生的显著独立预测因素是口服避孕药的使用（β = -0.174，P < 0.001）、饮酒（β = 0.188，P < 0.001）、焦虑（β = -0.189，P = 0.001）、抑郁症状负担重（β = 0.191，P = 0.001）以及对发育异常/癌前病变术语含义的了解不足（β = -0.187，P < 0.001）。在诊断程序前巴氏涂片检查结果呈阳性的女性中，心理社会负担——对信息/支持的满意度发生的显著独立预测因素是心理困扰（β = -0.210，P = 0.001）。提供信息以增进对发育异常/癌前病变术语的理解，以及确定哪些女性有心理社会负担风险，可能有助于防止在收到宫颈癌筛查阳性结果的女性中出现这种潜在危害，并可能促进她们接受进一步诊断程序的意愿。
