Morrow E L, Medina M A
Pharmacol Biochem Behav. 1986 Jan;24(1):55-60. doi: 10.1016/0091-3057(86)90044-4.
The effect of ethanol and pentobarbital narcosis on 2-deoxyglucose uptake into brain synaptosomes prepared from inbred C57BL/6J and DBA/2J mice which exhibit differential central sensitivity to ethanol and heterogeneous ICR mice was examined. A reversible depression of synaptosomal uptake was exhibited in all strains administered ethanol acutely, occurring at 2 min in ICR and C57BL/6J mice and 15 min in DBA/2J. Uptake returned to control values in all strains at 30 min although the mice remained intoxicated. Brain glucose concentration was significantly elevated at this time. Pentobarbital administration was without effect on synaptosomal hexose transport in DBA/2J and C57BL/6J mice but increased it significantly in ICR mice at 30 min. Pentobarbital anesthesia did not alter brain glucose concentration. No correlation was apparent between synaptosomal 2-deoxyglucose uptake and differential CNS sensitivity to ethanol and pentobarbital. The effects of ethanol and pentobarbital on neuronal hexose transport is discussed with respect to reported changes in glycolytic metabolism produced by these agents.
研究了乙醇和戊巴比妥麻醉对由近交系C57BL/6J和DBA/2J小鼠（它们对乙醇表现出不同的中枢敏感性）以及异质ICR小鼠制备的脑突触体摄取2-脱氧葡萄糖的影响。急性给予乙醇的所有品系均出现突触体摄取的可逆性抑制，ICR和C57BL/6J小鼠在2分钟时出现，DBA/2J小鼠在15分钟时出现。尽管小鼠仍处于醉酒状态，但在30分钟时所有品系的摄取均恢复到对照值。此时脑葡萄糖浓度显著升高。给予戊巴比妥对DBA/2J和C57BL/6J小鼠的突触体己糖转运没有影响，但在30分钟时显著增加了ICR小鼠的突触体己糖转运。戊巴比妥麻醉未改变脑葡萄糖浓度。突触体2-脱氧葡萄糖摄取与对乙醇和戊巴比妥的不同中枢神经系统敏感性之间没有明显的相关性。关于这些药物所报道的糖酵解代谢变化，讨论了乙醇和戊巴比妥对神经元己糖转运的影响。
