三种小鼠品系中的乙醇敏感性与膜脂组成

Ethanol sensitivity and membrane lipid composition in three strains of mouse.

作者信息

La Droitte P, Lamboeuf Y, de Saint Blanquat G

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(2):351-6. doi: 10.1016/0742-8413(84)90027-6.

Abstract

Strains of mouse (Swiss OF 1, DBA/2J Ico and C57 BL/6J Ico) with different sensitivities to the hypnotic effects of acute ethanol administration were also found to have differences in fatty acid composition in synaptosomal and erythrocyte membrane phospholipids. Chronic ethanol treatment altered membrane fatty acid composition in quantitatively different ways depending on whether the mice developed tolerance (DBA, C57) or not (Swiss). These results support the hypothesis that membrane lipid composition plays a role in the sensitivity to the effects of ethanol.

摘要

对急性乙醇给药催眠作用具有不同敏感性的小鼠品系（瑞士OF1、DBA/2J Ico和C57 BL/6J Ico），其突触体和红细胞膜磷脂中的脂肪酸组成也存在差异。慢性乙醇处理以定量不同的方式改变了膜脂肪酸组成，这取决于小鼠是否产生耐受性（DBA、C57）或未产生耐受性（瑞士小鼠）。这些结果支持了膜脂质组成在对乙醇作用的敏感性中起作用这一假说。