College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, China.
Finance Office, Inner Mongolia Minzu University, Tongliao 028000, China.
Int J Mol Sci. 2024 Oct 12;25(20):10995. doi: 10.3390/ijms252010995.
The prevalence of psychiatric disorders and neurodegenerative diseases is steadily increasing, placing a significant burden on both society and individuals. Given the intricate and multifaceted nature of these diseases, the precise underlying mechanisms remain elusive. Consequently, there is an increasing imperative to investigate the mechanisms, identify specific target sites for effective treatment, and provide for accurate diagnosis of patients with these diseases. Numerous studies have revealed significant alterations in the expression of long non-coding RNAs (lncRNAs) in psychiatric disorders and neurodegenerative diseases, suggesting their potential to increase the probability of these diseases. Moreover, these findings propose that lncRNAs could be used as highly valuable biomarkers in diagnosing and treating these diseases, thereby offering novel insights for future clinical interventions. The review presents a comprehensive summary of the origin, biological functions, and action mechanisms of lncRNAs, while exploring their implications in the pathogenesis of psychiatric disorders and neurodegenerative diseases and their potential utility as biomarkers.
精神疾病和神经退行性疾病的患病率稳步上升，给社会和个人都带来了巨大的负担。鉴于这些疾病的复杂和多方面的性质，其确切的潜在机制仍难以捉摸。因此，越来越有必要研究这些疾病的机制，确定有效的治疗的具体靶点，并为这些疾病的患者提供准确的诊断。许多研究表明，精神疾病和神经退行性疾病中长链非编码 RNA（lncRNA）的表达存在显著改变，表明它们可能增加这些疾病的发生概率。此外，这些发现表明，lncRNA 可以用作诊断和治疗这些疾病的非常有价值的生物标志物，从而为未来的临床干预提供新的见解。本综述全面总结了 lncRNA 的起源、生物学功能和作用机制，探讨了它们在精神疾病和神经退行性疾病发病机制中的意义及其作为生物标志物的潜在应用。
