Department of Urology and Andrology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, Poland.
Department of Cardiology and Cardiac Surgery, 10th Military Research Hospital and Polyclinic, Powstańców Warszawy 5, 85-681 Bydgoszcz, Poland.
Int J Mol Sci. 2024 Oct 14;25(20):11037. doi: 10.3390/ijms252011037.
Platelet-rich plasma (PRP) therapy holds promise for treating various clinical conditions. The activation process is crucial in releasing growth factors and cytokines from platelets, enhancing the therapeutic properties of PRP. Standard activation methods involve autologous thrombin or collagen, with variations in efficacy and growth factor release. This study explores the impact of acetylsalicylic acid (ASA), a commonly used antiplatelet drug, on PRP activation. The results indicate that non-activated PRP extracted from the whole blood of ASA-treated patients exhibits increased inflammatory cytokine concentrations, notably TNFa. After activation with autologous thrombin/CaCl or collagen IV, the measured fluorescence intensities suggest varying release patterns between treated and non-treated groups. Understanding the influence of ASA on platelet activation holds implications for personalized medicine and optimizing outcomes for individual patients undergoing PRP therapy. This research sheds light on the potential challenges associated with using antiplatelet drugs, emphasizing the need for careful consideration in tailoring PRP-based regenerative therapies.
富血小板血浆（PRP）治疗在治疗各种临床病症方面具有广阔的前景。血小板的激活过程对于释放生长因子和细胞因子至关重要，可增强 PRP 的治疗特性。标准的激活方法涉及自体凝血酶或胶原蛋白，其疗效和生长因子释放存在差异。本研究探讨了常用抗血小板药物乙酰水杨酸（ASA）对 PRP 激活的影响。结果表明，来自接受 ASA 治疗患者的全血提取的非激活 PRP 表现出增加的炎症细胞因子浓度，特别是 TNFa。在用自体凝血酶/CaCl 或胶原蛋白 IV 激活后，测量的荧光强度表明，在治疗组和未治疗组之间存在不同的释放模式。了解 ASA 对血小板激活的影响对于个体化医学和优化接受 PRP 治疗的个体患者的结果具有重要意义。这项研究揭示了与使用抗血小板药物相关的潜在挑战，强调了在制定基于 PRP 的再生治疗方案时需要谨慎考虑。
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