Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, 35128 Padova, Italy.
Department of Oncology, University of Torino, 10060 Candiolo, Italy.
Int J Mol Sci. 2024 Oct 20;25(20):11284. doi: 10.3390/ijms252011284.
Angiogenesis, the process of formation of new blood vessels from pre-existing vasculature, is essential for tumor growth and metastasis. Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF) signaling is a powerful tool to combat tumor growth; however, anti-tumor angiogenesis therapy has shown limited efficacy, with survival benefits ranging from only a few weeks to months. Compensation by upregulation of complementary growth factors and switches to different modes of vascularization have made these types of therapies less effective. Recent evidence suggests that targeting specific players in endothelial metabolism is a valuable therapeutic strategy against tumor angiogenesis. Although it is clear that metabolism can modulate the translational machinery, the reciprocal relationship between metabolism and mRNA translational control during tumor angiogenesis is not fully understood. In this review, we explore emerging examples of how endothelial cell metabolism affects mRNA translation during the formation of blood vessels. A deeper comprehension of these mechanisms could lead to the development of innovative therapeutic strategies for both physiological and pathological angiogenesis.
血管生成，即从预先存在的脉管系统中形成新血管的过程，对于肿瘤生长和转移至关重要。针对血管内皮生长因子 (VEGF) 信号的抗血管生成治疗是对抗肿瘤生长的有力工具；然而，抗肿瘤血管生成治疗的效果有限，仅能延长生存时间数周至数月。通过上调互补生长因子和切换到不同的血管生成模式进行补偿，使得这些类型的治疗效果降低。最近的证据表明，靶向内皮细胞代谢中的特定参与者是一种针对肿瘤血管生成的有价值的治疗策略。尽管很明显代谢可以调节翻译机制，但在肿瘤血管生成过程中代谢和 mRNA 翻译控制之间的这种相互关系还不完全清楚。在这篇综述中，我们探讨了内皮细胞代谢如何在血管形成过程中影响 mRNA 翻译的一些新实例。更深入地理解这些机制可能会为生理和病理血管生成的创新治疗策略的发展提供依据。
