• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

更新临床实践:改善儿童腺样体扁桃体切除术的围手术期疼痛管理

Updating Clinical Practice: Improving Perioperative Pain Management for Adeno-Tonsillectomy in Children.

作者信息

Redondo-Enríquez Juan Manuel, Rivas-Medina María, Galán-Mateos Manuel María

机构信息

Hospital de Mérida, 06800 Mérida, Badajoz, Spain.

出版信息

Children (Basel). 2024 Sep 29;11(10):1190. doi: 10.3390/children11101190.

DOI:10.3390/children11101190
PMID:39457155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11505956/
Abstract

BACKGROUND/OBJECTIVE: Perioperative acute pain management in pediatric patients is essential to reduce complications. Adenoidectomy-Tonsillectomy are surgical procedures requiring pain control, and risk minimization for postoperative bleeding, nausea, and vomiting. Despite their known secondary effects, the use of opioid analgesics is still preponderant in pediatric perioperative management. We performed a comprehensive review on adeno-tonsillectomy perioperative pain management in children. We developed and implemented a multimodal analgesia protocol aimed to improve patients' pain management while consistently reducing opioids use.

METHODS/RESULTS: relevant Information was summarized, then compared to our clinical needs. Learnings were used to create and implement a multimodal analgesia protocol that we use in patients 3-9 years-old undergoing adenoidectomy/tonsillectomy. The full protocol is presented. Analgesic strategies have emerged to reduce or avoid the use of opioids. Among these strategies, combining different non-opioid analgesics (Ibuprofen, Paracetamol, Metamizole) has been shown to be an effective and safe pharmacological strategy when implemented as part of perioperative multimodal analgesia protocols. Considerable evidence associating the use of NSAIDs with a bigger risk of postoperative bleeding does not exist.

CONCLUSIONS

Perioperative management of adenotonsillectomy pain should include preventive and multimodal analgesia, which have shown to provide significantly more effective analgesia than some opioid regimens. Ibuprofen offers highly effective analgesia for postoperative pain, particularly when combined with acetaminophen.

摘要

背景/目的:小儿患者围手术期急性疼痛管理对于减少并发症至关重要。腺样体扁桃体切除术是需要进行疼痛控制并将术后出血、恶心和呕吐风险降至最低的外科手术。尽管已知阿片类镇痛药有副作用,但在小儿围手术期管理中其使用仍然占主导地位。我们对儿童腺样体扁桃体切除术围手术期疼痛管理进行了全面综述。我们制定并实施了一种多模式镇痛方案,旨在改善患者的疼痛管理,同时持续减少阿片类药物的使用。

方法/结果:对相关信息进行了总结,然后与我们的临床需求进行比较。所得经验用于创建并实施一种多模式镇痛方案,我们将其用于3至9岁接受腺样体切除术/扁桃体切除术的患者。完整方案已列出。已出现减少或避免使用阿片类药物的镇痛策略。在这些策略中,将不同的非阿片类镇痛药(布洛芬、对乙酰氨基酚、安乃近)联合使用作为围手术期多模式镇痛方案的一部分时,已被证明是一种有效且安全的药理学策略。不存在将非甾体抗炎药的使用与术后出血风险增加相关的大量证据。

结论

腺样体扁桃体切除术疼痛的围手术期管理应包括预防性和多模式镇痛,这已被证明比某些阿片类药物方案能提供更有效的镇痛效果。布洛芬对术后疼痛有高效的镇痛作用,尤其是与对乙酰氨基酚联合使用时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5cc/11505956/1cc8e652d542/children-11-01190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5cc/11505956/1cc8e652d542/children-11-01190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5cc/11505956/1cc8e652d542/children-11-01190-g001.jpg

相似文献

1
Updating Clinical Practice: Improving Perioperative Pain Management for Adeno-Tonsillectomy in Children.更新临床实践:改善儿童腺样体扁桃体切除术的围手术期疼痛管理
Children (Basel). 2024 Sep 29;11(10):1190. doi: 10.3390/children11101190.
2
Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children.布洛芬或罗非昔布联合对乙酰氨基酚用于儿童扁桃体切除术后镇痛的双盲、安慰剂对照研究
Br J Anaesth. 2002 Jan;88(1):72-7. doi: 10.1093/bja/88.1.72.
3
Analgesic effectiveness, pharmacokinetics, and safety of a paracetamol/ibuprofen fixed-dose combination in children undergoing adenotonsillectomy: A randomized, single-blind, parallel group trial.对乙酰氨基酚/布洛芬固定剂量复方制剂用于行腺扁桃体切除术儿童的镇痛效果、药代动力学及安全性:一项随机、单盲、平行组试验
Paediatr Anaesth. 2018 Dec;28(12):1087-1095. doi: 10.1111/pan.13517. Epub 2018 Oct 29.
4
Parental assessment of pain control following pediatric adenotonsillectomy: Do opioids make a difference?小儿腺样体扁桃体切除术后家长对疼痛控制的评估:阿片类药物有作用吗?
Int J Pediatr Otorhinolaryngol. 2020 Jul;134:110045. doi: 10.1016/j.ijporl.2020.110045. Epub 2020 Apr 10.
5
The development of an opioid sparing anesthesia protocol for pediatric ambulatory tonsillectomy and adenotonsillectomy surgery-A quality improvement project.小儿门诊扁桃体切除术和腺样体扁桃体切除术的阿片类药物节约麻醉方案的制定——一项质量改进项目。
Paediatr Anaesth. 2019 Jul;29(7):682-689. doi: 10.1111/pan.13662. Epub 2019 Jun 19.
6
Opioid-Sparing Analgesia Impacts the Perioperative Anesthetic Management in Major Abdominal Surgery.阿片类药物节约型镇痛对大型腹部手术围手术期麻醉管理的影响。
Medicina (Kaunas). 2022 Mar 28;58(4):487. doi: 10.3390/medicina58040487.
7
Nonopioid, Multimodal Analgesia as First-line Therapy After Otolaryngology Operations: Primer on Nonsteroidal Anti-inflammatory Drugs (NSAIDs).耳鼻喉手术后一线治疗的非阿片类、多模式镇痛:非甾体抗炎药(NSAIDs)概述。
Otolaryngol Head Neck Surg. 2021 Apr;164(4):712-719. doi: 10.1177/0194599820947013. Epub 2020 Aug 18.
8
Comparison of Oral Loading Dose to Intravenous Acetaminophen in Children for Analgesia After Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial.扁桃体切除和腺样体切除术后儿童口服对乙酰氨基酚负荷剂量与静脉注射对乙酰氨基酚镇痛效果的比较:一项随机临床试验。
Anesth Analg. 2021 Dec 1;133(6):1568-1576. doi: 10.1213/ANE.0000000000005678.
9
Opioid-free anesthesia for adenotonsillectomy in children.儿童腺样体扁桃体切除术的无阿片类麻醉。
Int J Pediatr Otorhinolaryngol. 2021 Jan;140:110501. doi: 10.1016/j.ijporl.2020.110501. Epub 2020 Nov 27.
10
Postoperative analgesia and vomiting, with special reference to day-case surgery: a systematic review.术后镇痛与呕吐,特别涉及日间手术:一项系统评价
Health Technol Assess. 1998;2(12):1-236.

本文引用的文献

1
Ibuprofen for acute postoperative pain in children.布洛芬治疗儿童急性术后疼痛。
Cochrane Database Syst Rev. 2024 Jan 5;1(1):CD015432. doi: 10.1002/14651858.CD015432.pub2.
2
Treatment of recurrent acute tonsillitis-a systematic review and clinical practice recommendations.复发性急性扁桃体炎的治疗——一项系统评价与临床实践建议
Front Surg. 2023 Oct 10;10:1221932. doi: 10.3389/fsurg.2023.1221932. eCollection 2023.
3
Pain Evaluation and Treatment in Children: A Practical Approach.儿童疼痛评估与治疗:实用方法
Children (Basel). 2023 Jul 13;10(7):1212. doi: 10.3390/children10071212.
4
A Multi-Center Evaluation of the Pharmacokinetics and Safety of Intravenous Ibuprofen in Infants 1-6 Months of Age.一项多中心研究评估了静脉用布洛芬在 1-6 个月龄婴儿中的药代动力学和安全性。
Paediatr Drugs. 2023 Sep;25(5):585-593. doi: 10.1007/s40272-023-00576-9. Epub 2023 Jun 9.
5
The Analgesic Effects of the Addition of Intravenous Ibuprofen to a Multimodal Analgesia Regimen for Pain Management After Pediatric Cardiac Surgery: A Randomized Controlled Study.静脉注射布洛芬对小儿心脏手术后疼痛管理多模式镇痛方案的镇痛效果:一项随机对照研究。
J Cardiothorac Vasc Anesth. 2023 Mar;37(3):445-450. doi: 10.1053/j.jvca.2022.11.016. Epub 2022 Nov 22.
6
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.非甾体抗炎药(NSAIDs)在婴儿中的疗效和安全性:对过去 20 年文献的综合回顾。
Paediatr Drugs. 2022 Nov;24(6):603-655. doi: 10.1007/s40272-022-00514-1. Epub 2022 Sep 2.
7
Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants undergoing cleft palate repair: a randomized controlled trial.单次静脉注射布洛芬对行腭裂修复术的婴儿的超前镇痛效果:一项随机对照试验。
BMC Pediatr. 2021 Oct 22;21(1):466. doi: 10.1186/s12887-021-02907-6.
8
Pharmacologic management of post-tonsillectomy pain in children.儿童扁桃体切除术后疼痛的药物治疗
World J Otorhinolaryngol Head Neck Surg. 2021 May 29;7(3):186-193. doi: 10.1016/j.wjorl.2021.03.004. eCollection 2021 Jul.
9
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.儿童疼痛管理:围手术期和急诊科的 NSAID 使用。
Paediatr Drugs. 2021 Jul;23(4):361-372. doi: 10.1007/s40272-021-00449-z. Epub 2021 May 28.
10
Impact of a revised postoperative care plan on pain and recovery trajectory following pediatric tonsillectomy.修订术后护理计划对小儿扁桃体切除术后疼痛和恢复轨迹的影响。
Paediatr Anaesth. 2021 Jul;31(7):778-786. doi: 10.1111/pan.14187. Epub 2021 Apr 18.