Jiaerken Bahejuan, Liu Wei, Zheng Jiaojiao, Qu Weifeng, Wu Qiao, Ai Zhilong
Department of Surgery (Thyroid & Breast), Zhongshan Hospital, Fudan University, Shanghai 200032, China.
School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Biomedicines. 2024 Oct 21;12(10):2408. doi: 10.3390/biomedicines12102408.
(1) Background: Small ubiquitin-like modifiers (SUMOs) are pivotal in post-translational modifications, influencing various cellular processes, such as protein localization, stability, and genome integrity. (2) Methods: This review explores the SUMO family, including its isoforms and catalytic cycle, highlighting their significance in regulating key biological functions in thyroid cancer. We discuss the multifaceted roles of SUMOylation in DNA repair mechanisms, protein stability, and the modulation of receptor activities, particularly in the context of thyroid cancer. (3) Results: The aberrant SUMOylation machinery contributes to tumorigenesis through altered gene expression and immune evasion mechanisms. Furthermore, we examine the therapeutic potential of targeting SUMOylation pathways in thyroid cancer treatment, emphasizing the need for further research to develop effective SUMOylation inhibitors. (4) Conclusions: By understanding the intricate roles of SUMOylation in cancer biology, we can pave the way for innovative therapeutic strategies to improve outcomes for patients with advanced tumors.
（1）背景：小泛素样修饰物（SUMO）在翻译后修饰中起关键作用，影响各种细胞过程，如蛋白质定位、稳定性和基因组完整性。（2）方法：本综述探讨了SUMO家族，包括其亚型和催化循环，强调了它们在调节甲状腺癌关键生物学功能中的重要性。我们讨论了SUMO化在DNA修复机制、蛋白质稳定性和受体活性调节中的多方面作用，特别是在甲状腺癌的背景下。（3）结果：异常的SUMO化机制通过改变基因表达和免疫逃逸机制促进肿瘤发生。此外，我们研究了靶向SUMO化途径在甲状腺癌治疗中的治疗潜力，强调需要进一步研究以开发有效的SUMO化抑制剂。（4）结论：通过了解SUMO化在癌症生物学中的复杂作用，我们可以为创新治疗策略铺平道路，以改善晚期肿瘤患者的治疗效果。
