Brugger J M, Schneider J
Schweiz Med Wochenschr. 1986 Jan 11;116(2):44-9.
A histological study of 92 stenosed and calcified aortic valves is conducted to work out criteria with which to distinguish postrheumatic from degenerative calcification. The microscopic picture of a calcified aortic valve is fairly uniform and independent of a history of rheumatic fever. Thick walled and narrow muscular arteries with prominent elastic laminae are the only feature distinguishing calcified valves after rheumatic fever from valves showing degenerative calcification. This uniform morphology of the calcified aortic valves suggests a uniform process. The term "degenerative calcification" is used if this process occurs in an elderly patient, but a (histologically) nearly identical calcification is observed in younger people after rheumatic endocarditis or with congenitally bicuspid aortic valves. It is concluded that the basic process is the same (degenerative calcification) but that this degenerative process occurs earlier in patients with bicuspid valves or after rheumatic endocarditis.
对92个狭窄和钙化的主动脉瓣进行了组织学研究,以制定区分风湿性钙化和退行性钙化的标准。钙化主动脉瓣的微观图像相当一致,与风湿热病史无关。壁厚且狭窄、具有明显弹性膜的肌性动脉是区分风湿热后钙化瓣膜与显示退行性钙化瓣膜的唯一特征。钙化主动脉瓣的这种一致形态表明存在一个统一的过程。如果这个过程发生在老年患者身上,则使用“退行性钙化”一词,但在风湿性心内膜炎后或先天性二叶式主动脉瓣的年轻患者中也观察到(组织学上)几乎相同的钙化。结论是基本过程相同(退行性钙化),但这种退行性过程在二叶式瓣膜患者或风湿性心内膜炎后发生得更早。