Hendry S H, Jones E G, Emson P C, Lawson D E, Heizmann C W, Streit P
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Exp Brain Res. 1989;76(2):467-72. doi: 10.1007/BF00247904.
Calcium ions play a key role in many aspects of neuronal behavior and certain calcium binding proteins that may influence this behavior are differentially distributed in the central nervous system. In this study it is shown that immunoreactivity for calbindin-28 and for parvalbumin is localized in separate populations of inhibitory GABA interneurons in all areas of the neocortex of Old World monkeys. Virtually all GABA neurons show immunoreactivity for one or other calcium binding protein but, except for a few cells in layer IV, GABA cells do not show immunoreactivity for both proteins. Among the two cell populations, parvalbumin immunoreactivity characterizes basket neurons while calbindin immunoreactivity characterizes double bouquet neurons. These findings suggest that the two GABA cell types differ in their regulation of calcium homeostasis and may yield clues to their different roles in intracortical circuitry.
钙离子在神经元行为的许多方面起着关键作用，某些可能影响这种行为的钙结合蛋白在中枢神经系统中呈差异分布。本研究表明，在旧大陆猴新皮层的所有区域中，钙结合蛋白-28和小白蛋白的免疫反应性定位于不同的抑制性GABA中间神经元群体中。几乎所有的GABA神经元都对一种或另一种钙结合蛋白呈免疫反应性，但除了IV层中的少数细胞外，GABA细胞对这两种蛋白都不呈免疫反应性。在这两个细胞群体中，小白蛋白免疫反应性表征篮状神经元，而钙结合蛋白免疫反应性表征双花束神经元。这些发现表明，这两种GABA细胞类型在钙稳态调节方面存在差异，可能为它们在皮质内回路中的不同作用提供线索。
