Maurice Roch Listz, Dahdah Nagib
Centre de Recherche Charles-Le Moyne (CRCLM), Centre Intégré de Santé et des Services Sociaux de la Montérégie-Centre (CISSSMC), Longueuil, QC J4K 0A8, Canada.
Groupe Biomédical Montérégie, Centre Intégré de Santé et des Services Sociaux de la Montérégie-Centre (CISSSMC), Brossard, QC J4V 2H1, Canada.
J Clin Med. 2024 Oct 18;13(20):6220. doi: 10.3390/jcm13206220.
: In 2022, the World Stroke Organization said there were more than 12.2 million new cases of stroke each year, between all ages and sexes. Six and a half million people die each year from stroke. Ischemic stroke accounts for 7.6 million (62%) cases, with 3.3 million (51%) deaths. Stroke is mainly linked to the atherosclerosis of a large artery. : Since the carotid artery directly supplies the brain, we used age-dependent mechanical mapping on the healthy common carotid artery (CCA) with the aim of being able to predict and thus potentially prevent ischemic stroke. : We assessed the CCA stiffness of 95 healthy control (CTL) females (2.23-39.46 years) and 107 healthy CTL males (2.85-40 years). Cine-loops of B-mode CCA data were digitally recorded with conventional medical ultrasound devices. Arterial wall elastic moduli were estimated offline using a proprietary non-invasive imaging-based biomarker algorithm (ImBioMark). Statistical analyzes were carried out with Excel software. : Females showed a linear regression profile of CCA elastic moduli ranging from 41 ± 2 kPa to 54 ± 17 kPa (R = 0.88), while males showed one ranging from 38 ± 5 kPa to 63 ± 22 kPa (R = 0.83). For qualitative and quantitative illustrations, the elastic modulus data of CTLs were compared with those of subjects with Kawasaki disease and subjects born prematurely, respectively. : This study introduced some fundamental features of the mechanical evolution of the CCA as a function of age (2-40 years). Since atherosclerotic arteriopathy starts early in life, this gives the ability to predict risks of stroke and other cardiovascular diseases with the possibility of applying a more comprehensive range of potential preventive measures early in life. This is consistent with preventive medicine objectives which aim to be more predictive to implement pre-emptive measures as opposed to diagnostic and curative approaches.
2022年，世界卒中组织称，每年各年龄段和性别的卒中新增病例超过1220万例。每年有650万人死于卒中。缺血性卒中占760万例（62%），死亡330万例（51%）。卒中主要与大动脉粥样硬化有关。由于颈动脉直接为大脑供血，我们对健康的颈总动脉（CCA）进行了年龄依赖性力学测绘，目的是能够预测并因此潜在地预防缺血性卒中。我们评估了95名健康对照（CTL）女性（2.23 - 39.46岁）和107名健康CTL男性（2.85 - 40岁）的CCA硬度。使用传统医学超声设备对B模式CCA数据的电影环进行数字记录。使用专有的基于非侵入性成像的生物标志物算法（ImBioMark）离线估计动脉壁弹性模量。使用Excel软件进行统计分析。女性的CCA弹性模量线性回归曲线范围为41±2 kPa至54±17 kPa（R = 0.88），而男性的范围为38±5 kPa至63±22 kPa（R = 0.83）。为了进行定性和定量说明，分别将CTL的弹性模量数据与川崎病患者和早产儿的弹性模量数据进行了比较。这项研究介绍了CCA力学演变随年龄（2 - 40岁）变化的一些基本特征。由于动脉粥样硬化性动脉病变在生命早期就开始了，这使得能够预测卒中及其他心血管疾病的风险，并有可能在生命早期实施更全面的潜在预防措施。这与预防医学的目标一致，即旨在更具预测性以实施预防措施，而不是诊断和治疗方法。
