Correlation Analysis of the Transcriptome and Gut Microbiota in Resistance to .

is a major pathogenic bacterium that poses a significant threat to salmonid fish. Yadong County, located in the Xizang Autonomous Region, is renowned for its characteristic industry of aquaculture. In recent years, the outbreak of Bacterial Gill Disease (BGD) has led to substantial economic losses for farmers. Our prior research identified as one of the primary culprits behind BGD. To mitigate the impact of on , we conducted a comprehensive study aimed at identifying genes associated with resistance to . This involved transcriptome sequencing and 16S rRNA sequencing of intestinal flora, providing valuable insights for the study of disease resistance in . In this study, we identified 324 genera with 5171 ASVs in the susceptible group and 293 genera with 5669 ASVs in the resistant group. Notably, and were common bacteria present in the salmon's gut, and their proportions remained relatively stable before and after infection. , with its antagonistic relationship with Aeromonas, may play a crucial role in the salmon's defense against . Several related genes were identified, including , , , , , , , , , and .