Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Division of Animal and Dairy Sciences, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Republic of Korea.
J Microbiol Biotechnol. 2020 Oct 28;30(10):1443-1457. doi: 10.4014/jmb.2005.05040.
The emergence and spread of antimicrobial resistance in pathogenic bacteria of fish and shellfish have caused serious concerns in the aquaculture industry, owing to the potential health risks to humans and animals. Among these bacteria, , which is one of the most important primary pathogens in salmonids, is responsible for significant economic losses in the global aquaculture industry, especially in salmonid farming because of its severe infectivity and acquisition of antimicrobial resistance. Therefore, interest in the use of alternative approaches to prevent and control infections has increased in recent years, and several applications of bacteriophages (phages) have provided promising results. For several decades, and phages infecting this fish pathogen have been thoroughly investigated in various research areas including aquaculture. The general overview of phage usage to control bacterial diseases in aquaculture, including the general advantages of this strategy, has been clearly described in previous reviews. Therefore, this review specifically focuses on providing insights into the phages infecting , from basic research to biotechnological application in aquaculture, as well as recent advances in the study of .
鱼类和贝类病原菌中抗菌药物耐药性的出现和传播引起了水产养殖业的严重关注，因为这可能对人类和动物的健康造成威胁。在这些细菌中，鲑鱼弧菌是鲑鱼科鱼类最重要的原发性病原体之一，由于其高度传染性和获得抗菌药物耐药性，给全球水产养殖业造成了巨大的经济损失，尤其是在鲑鱼养殖中。因此，近年来人们对替代方法预防和控制弧菌感染的兴趣有所增加，噬菌体（phages）的几种应用已经取得了有希望的结果。几十年来，在水产养殖等各个研究领域中，已经对感染这种鱼类病原体的 和噬菌体进行了深入研究。以前的综述清楚地描述了噬菌体在水产养殖中控制细菌性疾病的一般用途，包括这种策略的一般优势。因此，本综述特别侧重于从基础研究到水产养殖中的生物技术应用，提供有关感染 的噬菌体的见解，以及弧菌研究的最新进展。
