Department of Gastroenterology, Hutt Valley Hospital, Wellington 5010, New Zealand.
Department of Gastroenterology, Middle Hospital, Auckland 6021, New Zealand.
Nutrients. 2024 Oct 10;16(20):3437. doi: 10.3390/nu16203437.
Eosinophilic oesophagitis (EoE) is an immune-mediated oesophageal disorder causing dysphagia. Patients with EoE experience reduced QoL due to symptoms; however, this has not been assessed in the New Zealand population. The aim of this study was to assess QoL in patients with EoE in New Zealand.
This observational study recruited participants from two New Zealand hospitals. Records were reviewed to confirm diagnoses, and consenting participants completed an electronic survey, consisting of the Dysphagia Symptom Questionnaire (DSQ) score and the QoL-specific EoE (EoE-QoL-A) questionnaire score. Correlation analysis examined the relationship between the DSQ and EoE-QoL-A scores. Differences in baseline variables were assessed. Univariate logistic regression assessed the association of variables with disease activity and QoL.
Fifty-four participants responded, and four were excluded due to incomplete surveys. The majority (76%) were male, and the median age was 47 years (IQR 42-58). The median DSQ was 49 (IQR 0-60), and the median EoE-QoL-A score was 68 (IQR 48-80). A reduced EoE-QoL-A score was associated with active disease (OR = 0.96,95% CI 0.926-0.995). Significant associations were found between disease activity and overall EoE-QoL-A score (r = -0.37, < 0.01) as well as the sub-categories eating and diet (r = -0.54, < 0.001), social (r = 0.30, < 0.05), and emotional impact (r = -0.44, < 0.01). The EOE-QoL-A score was higher in those on PPI (75 vs. 60, = 0.02).
This study identified a decreased quality of life (QoL) in individuals with EoE in New Zealand, aligning with international literature. The increased DSQ scores suggest a possible gap in current management approaches. The correlation between the DSQ and QoL highlights the need for improved care models of care for EoE.
嗜酸性食管炎（EoE）是一种免疫介导的食管疾病，导致吞咽困难。EoE 患者由于症状而降低了生活质量，但尚未在新西兰人群中进行评估。本研究的目的是评估新西兰 EoE 患者的生活质量。
这项观察性研究从新西兰的两家医院招募了参与者。回顾病历以确认诊断，同意的参与者完成了电子调查，包括吞咽困难症状问卷（DSQ）评分和特定于生活质量的 EoE（EoE-QoL-A）问卷评分。相关性分析检查了 DSQ 和 EoE-QoL-A 评分之间的关系。评估了基线变量的差异。单变量逻辑回归评估了变量与疾病活动和生活质量的关联。
54 名参与者做出了回应，由于调查不完整，有 4 人被排除在外。大多数（76%）为男性，中位年龄为 47 岁（IQR 42-58）。中位 DSQ 为 49（IQR 0-60），中位 EoE-QoL-A 评分为 68（IQR 48-80）。EoE-QoL-A 评分降低与疾病活动有关（OR=0.96，95%CI 0.926-0.995）。还发现疾病活动与整体 EoE-QoL-A 评分（r=-0.37，<0.01）以及饮食（r=-0.54，<0.001）、社会（r=0.30，<0.05）和情绪影响（r=-0.44，<0.01）等亚类之间存在显著相关性。接受 PPI 治疗的患者 EoE-QoL-A 评分较高（75 分比 60 分，=0.02）。
本研究发现新西兰 EoE 患者的生活质量下降，与国际文献一致。DSQ 评分升高表明当前管理方法可能存在差距。DSQ 和生活质量之间的相关性突出了需要改善 EoE 的护理模式。
