Calcified intracranial metastases from breast carcinoma with a therapeutic response to tamoxifen therapy.

A 66-year-old woman with a subacute onset of mild dementia and headaches was discovered to have multiple large, hyperdense lesions on cranial CT scan. Biopsy showed poorly differentiated adenocarcinoma with necrosis and dystrophic calcification, which represented an unusual initial manifestation of metastatic breast carcinoma after a seven-year disease-free period. Neurologic symptoms improved with tamoxifen therapy.