Dong Donghua, Zhan Jilai, Liao Guoxing, Zhu Tong, Yu Qianqian, Zhang Wei, Wang Linge
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, South China University of Technology, Guangzhou 510640, China.
Molecules. 2024 Oct 11;29(20):4802. doi: 10.3390/molecules29204802.
The challenge of producing polymer vesicles remains difficult, despite numerous attempts to modulate the kinetics of polymer vesicle budding and achieve precise control over the membrane characteristics. An innovative approach that incorporates the use of copolymer-loaded single-emulsion droplets is proposed to address this challenge. This method enables the precise manipulation of micelles and polymer vesicles' composition, structures and dimensions. The emulsion contracts and forms microspheres when the copolymer concentrations exceed > 0.5 wt%, resulting in the formation of nano polymer vesicles. Conversely, the copolymer spontaneously forms micro polymer vesicles and micelles through vesicle budding at lower concentrations. The spontaneous production of vesicles and micelles can be induced by modifying the copolymer concentration in the emulsion. Our discoveries have a significant impact relative to the development of copolymer membranes and contribute to an enhanced comprehension of the mass manufacturing of polymer vesicles from single emulsions.
尽管人们多次尝试调节聚合物囊泡出芽的动力学并实现对膜特性的精确控制，但生产聚合物囊泡仍然具有挑战性。为应对这一挑战，提出了一种结合使用负载共聚物的单乳液滴的创新方法。该方法能够精确操纵胶束以及聚合物囊泡的组成、结构和尺寸。当共聚物浓度超过0.5 wt%时，乳液收缩并形成微球，从而形成纳米聚合物囊泡。相反，在较低浓度下，共聚物通过囊泡出芽自发形成微聚合物囊泡和胶束。通过改变乳液中共聚物的浓度，可以诱导囊泡和胶束的自发产生。我们的发现对于共聚物膜的开发具有重大影响，并有助于加深对从单乳液大规模制造聚合物囊泡的理解。
