Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230012, China.
Molecules. 2024 Oct 16;29(20):4901. doi: 10.3390/molecules29204901.
A total of twelve previously unreported isoindolin-1-one compounds, erinacenones A-L (-), were isolated from liquid cultures of the medicinal fungus . Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of was determined by comparing its optical rotations with values reported in the literature. The most distinctive feature of these compounds is that their nitrogen atoms are connected to different parts of the special structure moieties. Among them, compounds and , as well as and , are two pairs of isomers differing only by a small change in the position of one double bond. Compounds and were found to show cytotoxic activities, with IC values of 24.7 and 18.4 μM, respectively, against MCF-7 cell lines.
从药用真菌的液体培养物中分离得到了 12 种以前未报道过的异吲哚啉-1-酮化合物，命名为 erinacenones A-L（-）。基于光谱数据分析确定了它们的结构。通过将其旋光度与文献中报道的值进行比较，确定了 的绝对构型。这些化合物的最显著特征是它们的氮原子连接到特殊结构部分的不同部位。其中，化合物 和 ，以及 和 ，是两对仅在一个双键位置略有变化的差向异构体。化合物 和 被发现具有细胞毒性活性，对 MCF-7 细胞系的 IC 值分别为 24.7 和 18.4 μM。
