Gysin P
Adv Ophthalmol. 1979;39:210-32.
Rapidly proliferating tissue incorporates more phosphorus than normal. Thus, following administration of radioactive phosphorus (32P), tumors emit increased amounts of radiation which can be detected. With the proper test technique, a correct diagnosis rate of 96-100% is quoted in the literature. By comparison, between 4 and 20% of all eyes enucleated for suspected malignant melanoma without prior 32P testing contained no neoplasm histologically. The radiation exposure is minimal due to the short half-life of 32P and the low penetration of beta-particles. However, the test usually involves a small operation (conjunctiva and Tenon incision). Testing with gamma rays, however, is not yet wholly satisfactory due to the lack of a suitable gamma-ray detector.
快速增殖的组织比正常组织摄取更多的磷。因此,在给予放射性磷(32P)后,肿瘤会发出更多可检测到的辐射。采用适当的检测技术,文献报道的正确诊断率为96 - 100%。相比之下,在所有因疑似恶性黑色素瘤而摘除眼球且未进行32P检测的病例中,有4%至20%的病例经组织学检查未发现肿瘤。由于32P的半衰期短且β粒子穿透力低,辐射暴露极小。然而,该检测通常需要一个小手术(结膜和眼球筋膜切开)。不过,由于缺乏合适的γ射线探测器,γ射线检测目前还不完全令人满意。