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[眼科中的32P试验]

[The 32P test in ophthalmology].

作者信息

Gysin P

出版信息

Adv Ophthalmol. 1979;39:210-32.

PMID:394593
Abstract

Rapidly proliferating tissue incorporates more phosphorus than normal. Thus, following administration of radioactive phosphorus (32P), tumors emit increased amounts of radiation which can be detected. With the proper test technique, a correct diagnosis rate of 96-100% is quoted in the literature. By comparison, between 4 and 20% of all eyes enucleated for suspected malignant melanoma without prior 32P testing contained no neoplasm histologically. The radiation exposure is minimal due to the short half-life of 32P and the low penetration of beta-particles. However, the test usually involves a small operation (conjunctiva and Tenon incision). Testing with gamma rays, however, is not yet wholly satisfactory due to the lack of a suitable gamma-ray detector.

摘要

快速增殖的组织比正常组织摄取更多的磷。因此,在给予放射性磷(32P)后,肿瘤会发出更多可检测到的辐射。采用适当的检测技术,文献报道的正确诊断率为96 - 100%。相比之下,在所有因疑似恶性黑色素瘤而摘除眼球且未进行32P检测的病例中,有4%至20%的病例经组织学检查未发现肿瘤。由于32P的半衰期短且β粒子穿透力低,辐射暴露极小。然而,该检测通常需要一个小手术(结膜和眼球筋膜切开)。不过,由于缺乏合适的γ射线探测器,γ射线检测目前还不完全令人满意。

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