Packer S, Shields J A, Christman D R, Wolf A P, Atkins H L
Invest Ophthalmol Vis Sci. 1980 Apr;19(4):386-92.
The concentration of radioactive phosphorus in uveal melanoma and normal parts of the eye was determined in vitro in 14 eyes. The eyes were enucleated after a positive 32P uptake test. Portions of the melanoma as well as normal choroid, retina, sclera, lens, and vitreous were analyzed. The 32P uptake test had been performed at various intervals after intravenous administration of 32P from 24 to 556 hr. The in vitro uptake of 32P was compared to cell type, tumor volume, time of testing, percent uptake measured clinically, and specific activity. The only positive correlation was between percent uptake measured clinically and 32P concentration (dpm/gm). A higher concentration of phosphorus in melanoma resulted when carrier-free 32P was used. A negative correlation existed between number of hours from injection to clinical measurement of percent uptake, although melanoma to normal choroid ratios did not change from 24 to 72 hr. No correlation was found between uptake and tumor volume. The sample was small; however, we saw no correlation between 32P uptake and degree of malignancy.
对14只眼睛进行了体外实验，测定葡萄膜黑色素瘤及眼睛正常部位中放射性磷的浓度。在32P摄取试验呈阳性后摘除眼球。对黑色素瘤部分以及正常脉络膜、视网膜、巩膜、晶状体和玻璃体进行了分析。在静脉注射32P后24至556小时的不同时间间隔进行了32P摄取试验。将体外32P摄取与细胞类型、肿瘤体积、检测时间、临床测量的摄取百分比及比活度进行了比较。唯一的正相关是临床测量的摄取百分比与32P浓度（每分钟衰变数/克）之间的相关性。使用无载体32P时，黑色素瘤中的磷浓度更高。从注射到临床测量摄取百分比的小时数之间存在负相关，尽管从24小时到72小时黑色素瘤与正常脉络膜的比率没有变化。未发现摄取与肿瘤体积之间的相关性。样本量较小；然而，我们未发现32P摄取与恶性程度之间的相关性。
