Rao N A, Gamel J W, McMahon R T, McLean I W
Invest Ophthalmol Vis Sci. 1977 Jan;16(1):98-102.
The radioactive phosphorus uptake of 30 samples fron nine uveal melanomas was determined by liquid scintillation counting. These in vitro measurements correlated positively with clinical (in vivo) 32P values and with the number of mitotic figures and percentage of epithelioid cells (PEC) within the specimens. Three possible explanations were found for the failure of previous workers to demonstrate a correlation between cell type and clinical 32P. (1) Cell type, using Callender's classification, provides only a crude estimate of the PEC within a tumor; in particular, tumors of mixed cell type can vary widely in epithelioid cell content. (2) The rate of 32P absorption is not su-ficiently sensitive to distinguish spindle cell tumors from mixed cell tumors with a low PEC. (3) Clinical 32P measurements may be affected by extraneous factors that cause large deviations from the expected values.
通过液体闪烁计数法测定了来自9例葡萄膜黑色素瘤的30个样本的放射性磷摄取量。这些体外测量值与临床（体内）32P值、标本中的有丝分裂指数以及上皮样细胞（PEC）百分比呈正相关。对于之前的研究人员未能证明细胞类型与临床32P之间存在相关性，发现了三种可能的解释。（1）使用卡伦德分类法的细胞类型仅对肿瘤内的PEC提供粗略估计；特别是，混合细胞类型的肿瘤在上皮样细胞含量上可能有很大差异。（2）32P吸收速率不够灵敏，无法区分纺锤状细胞瘤和PEC含量低的混合细胞瘤。（3）临床32P测量可能受到导致与预期值有很大偏差的外部因素的影响。
