Laboratory of Chromatography, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Laboratory of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Medicina (Kaunas). 2024 Sep 24;60(10):1561. doi: 10.3390/medicina60101561.
: Phenibut is a central nervous system drug that is registered and used in clinical practice as a prescription medication. In recent decades, the drug has become popular as a "nootropic and cognition enhancer" because of its active marketing as a dietary or food supplement sold online. This has resulted in a growing number of case reports on acute toxicity and withdrawal symptoms and has raised concerns about the quality of phenibut-containing products. : We used high-performance liquid chromatography with diode-array detection and ultra-performance liquid chromatography-mass spectrometry to investigate the quality of six phenibut-containing samples purchased from three internet suppliers. : Substantially lower levels of the active pharmaceutical ingredient than claimed on the packaging were found for three of the supplements tested. A considerably higher level of phenibut was present in one product. All online-purchased phenibut-containing capsules included declared and undeclared ingredients found in various dietary supplements claiming to have metabolic, neurotropic, antioxidant, anti-inflammatory, and neuroprotective properties. : The online-purchased phenibut products contained undeclared ingredients and the content of phenibut differed from the declared. The combinations of these additional ingredients with phenibut have not been tested for activity or safety and their use warrants further attention to avoid potential health problems.
苯海索是一种中枢神经系统药物，在临床实践中作为处方药物注册和使用。近几十年来，由于其被积极宣传为在线销售的膳食或食品补充剂，作为“益智药和认知增强剂”而广受欢迎。这导致越来越多的关于急性毒性和戒断症状的案例报告，并引起了对含苯海索产品质量的关注。
我们使用二极管阵列检测高效液相色谱法和超高效液相色谱-质谱法研究了从三个互联网供应商处购买的六种含苯海索样品的质量。
在所测试的三种补充剂中，有三种的活性药物成分含量明显低于包装上声称的水平。一种产品中的苯海索含量要高得多。所有在网上购买的含苯海索的胶囊均包含申报和未申报的成分，这些成分存在于各种声称具有代谢、神经、抗氧化、抗炎和神经保护特性的膳食补充剂中。
在网上购买的苯海索产品含有未申报的成分，且苯海索的含量与申报的含量不同。这些额外成分与苯海索的组合尚未经过活性或安全性测试，其使用需要进一步关注，以避免潜在的健康问题。
