Barkus Artūras, Baltrūnienė Vaida, Baušienė Justė, Baltrūnas Tomas, Barkienė Lina, Kazlauskaitė Paulina, Baušys Augustinas
Department of Pathology and Forensic Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Laboratory of Experimental Surgery and Oncology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Life (Basel). 2024 Sep 25;14(10):1227. doi: 10.3390/life14101227.
Opioid Use Disorder is a chronic condition characterized by compulsive opioid use despite negative consequences, resulting in severe health risks such as overdose and contraction of infectious diseases. High dropout rates in opioid agonist therapy highlight the need for more effective relapse prevention strategies. Animal and clinical studies indicate that opioids influence gut microbiota, which in turn plays a critical role in addiction development and alters behavioral responses to opioids. This study provides a comprehensive review of the literature on the effects of opioids on the gut microbiome and explores the potential of microbiome manipulation as a therapeutic target in opioid addiction.
阿片类物质使用障碍是一种慢性疾病，其特征是尽管存在负面后果仍强迫性使用阿片类物质，导致诸如过量用药和感染传染病等严重健康风险。阿片类激动剂治疗中的高脱落率凸显了对更有效预防复发策略的需求。动物和临床研究表明，阿片类物质会影响肠道微生物群，而肠道微生物群反过来在成瘾发展中起关键作用，并改变对阿片类物质的行为反应。本研究全面综述了关于阿片类物质对肠道微生物组影响的文献，并探讨了将微生物组调控作为阿片类成瘾治疗靶点的潜力。
