Stutts M J, Gatzy J T, Knowles M R, Cotton C U, Boucher R C
Toxicol Appl Pharmacol. 1986 Feb;82(2):360-7. doi: 10.1016/0041-008x(86)90213-9.
The functions of the epithelium that lines mammalian airways are potential targets for the toxic effects of reactive chemicals such as formaldehyde. We examined the effects of formaldehyde on bioelectric properties and ion permeation of excised canine and human bronchial epithelium. Concentration-dependent reductions in short-circuit current were induced in both tissues. Sodium absorption and transcellular chloride fluxes across canine bronchial epithelium were inhibited by 65 and 35%, respectively, by 10(-3) M formaldehyde. The QO2 of isolated dog bronchial epithelial cells was reduced by 32% by 10(-3) M formaldehyde. These results are consistent with an action of formaldehyde on cellular ion permeability but effects secondary to metabolic inhibition cannot be dismissed.
哺乳动物气道内衬的上皮组织功能是甲醛等活性化学物质毒性作用的潜在靶点。我们研究了甲醛对离体犬和人支气管上皮生物电特性和离子渗透的影响。两种组织均出现了短路电流随浓度增加而降低的情况。10⁻³ M甲醛分别抑制了犬支气管上皮细胞的钠吸收和跨细胞氯通量，抑制率分别为65%和35%。10⁻³ M甲醛使离体犬支气管上皮细胞的QO₂降低了32%。这些结果与甲醛对细胞离子通透性的作用一致，但不能排除代谢抑制的继发效应。
