Deng Huilin, Liu Fang, He Jingwei
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Materials (Basel). 2024 Oct 15;17(20):5040. doi: 10.3390/ma17205040.
This study aimed to enhance the performance of dental resin composites (DRCs) by increasing the content of inorganic fillers while addressing potential health risks associated with Bisphenol A (BPA). To achieve this, the BPA-based resin monomer Bis-GMA was replaced with BPA-free Bis-EFMA. The study then explored the impact of varying inorganic filler contents on the physiochemical properties of Bis-EFMA-based bulk-fill dental resin composites (BF-DRCs). Four distinct Bis-EFMA-based BF-DRCs were formulated, each with different inorganic filler contents ranging from 70 wt% to 76 wt%. The study tested the depth of cure (DOC), double-bond conversion (DC), water sorption (WS), solubility (SL), and cytotoxicity of the system. It notably investigated the effects of increasing filler content on mechanical properties through flexural strength (FS), flexural modulus (FM), Vickers microhardness (VHN), and wear resistance, as well as the impact on polymerization shrinkage, including volumetric shrinkage (VS) and shrinkage stress (SS). To assess the commercial application potential of Bis-EFMA-based BF-DRC, the research used the commercially available BF-DRC Filtek Bulk-Fill Posterior (FBF) as a control. The results indicated that a higher filler content did not affect the DOC of Bis-EFMA-based BF-DRCs. Inorganic fillers at higher concentrations significantly enhanced overall mechanical properties while significantly reducing volumetric shrinkage (VS; < 0.05). When the concentration of inorganic fillers in the resin system reached 76 wt%, most of the performance of the Bis-EFMA-based BF-DRC surpassed that of the commercial control FBF, except for FS, FM, and SS. These findings highlight the potential of Bis-EFMA-based BF-DRC as a long-term restorative material for dental applications.
本研究旨在通过增加无机填料的含量来提高牙科树脂复合材料（DRCs）的性能，同时解决与双酚A（BPA）相关的潜在健康风险。为实现这一目标，将基于BPA的树脂单体双酚A缩水甘油醚（Bis-GMA）替换为不含BPA的双酚E氟甲基丙烯酸酯（Bis-EFMA）。然后，该研究探讨了不同无机填料含量对基于Bis-EFMA的大块充填牙科树脂复合材料（BF-DRCs）物理化学性质的影响。制备了四种不同的基于Bis-EFMA的BF-DRCs，每种的无机填料含量不同，范围从70 wt%到76 wt%。该研究测试了该体系的固化深度（DOC）、双键转化率（DC）、吸水性（WS）、溶解度（SL）和细胞毒性。特别研究了填料含量增加对机械性能的影响，包括弯曲强度（FS）、弯曲模量（FM）、维氏显微硬度（VHN）和耐磨性，以及对聚合收缩的影响，包括体积收缩（VS）和收缩应力（SS）。为评估基于Bis-EFMA的BF-DRC的商业应用潜力，该研究使用市售的BF-DRC Filtek Bulk-Fill Posterior（FBF）作为对照。结果表明，较高的填料含量不会影响基于Bis-EFMA的BF-DRCs的DOC。较高浓度的无机填料显著提高了整体机械性能，同时显著降低了体积收缩（VS；P<0.05）。当树脂体系中无机填料的浓度达到76 wt%时，基于Bis-EFMA的BF-DRC的大多数性能超过了商业对照FBF，但FS、FM和SS除外。这些发现突出了基于Bis-EFMA的BF-DRC作为牙科应用长期修复材料的潜力。
