使用合成含氟甲基丙烯酸酯（DFMA）制备对变形链球菌具有抗粘附作用的无双酚A缩水甘油醚甲基丙烯酸酯（Bis-GMA）牙科树脂复合材料。
Preparation of Bis-GMA free dental resin composites with anti-adhesion effect against Streptococcus mutans using synthesized fluorine-containing methacrylate (DFMA).
作者信息
Zhang Shengcan, Liao Muzi, Liu Fang, Huang Xiangya, Mai Sui, He Jingwei
机构信息
College of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Department of Conservation Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
出版信息
J Mech Behav Biomed Mater. 2022 Jul;131:105263. doi: 10.1016/j.jmbbm.2022.105263. Epub 2022 May 4.
With purpose of preparing Bis-GMA free dental resin composites (DRCs) with anti-adhesion effect against Streptococcus mutans (S. mutans), a new fluorinated dimethacrylate (DFMA) was synthesized and used as base resin of DRCs. Two reactive diluents TEGDMA and SR833s were mixed with DFMA separately to prepare resin matrixes. After mixing with inorganic fillers, two DFMA based DRCs were obtained and named as DT (DFMA/TEGDMA) and DS (DFMA/SR833s) according to the resin matrix composition. Bis-GMA based DRC (BT) was used as control. The double bond conversion (DC), bacteria adhesion, mucin adsorption, contact angle, surface free energy, volumetric shrinkage (VS), shrinkage stress (SS), water sorption (WS) and solubility (SL), flexural strength (FS) and modulus (FM) before and after water immersion were investigated, and all the results were statistically analyzed with ANOVA analysis. The results showed that DT and DS had comparable (ρ > 0.05) surface free energy which was lower than that of BT (ρ < 0.05). Compared with BT, with the same surface roughness (ρ > 0.05), less amount of S. mutans was accumulated on the surface of DT and DS (ρ < 0.05). In all DRCs, the DS had the best resistance to mucin adsorption (ρ < 0.05) due to its high hydrophobicity. Compared with BT, both DFMA based DRCs had advantages such as lower VS and SS (ρ < 0.05), lower WS and SL (ρ < 0.05), and better water resistance. The DS, which had antibacterial adhesion effect, mucin adsorption resistance, lowest VS and SL (ρ < 0.05), and the highest FS and FM no matter before or after water immersion (ρ < 0.05) was considered to have the best comprehensive properties in all DRCs.
为了制备对变形链球菌具有抗粘附作用的不含双酚 A 缩水甘油醚甲基丙烯酸酯（Bis - GMA）的牙科树脂复合材料（DRCs），合成了一种新型氟化二甲基丙烯酸酯（DFMA）并将其用作 DRCs 的基础树脂。分别将两种活性稀释剂三乙二醇二甲基丙烯酸酯（TEGDMA）和 SR833s 与 DFMA 混合以制备树脂基体。与无机填料混合后，得到两种基于 DFMA 的 DRCs，并根据树脂基体组成将其命名为 DT（DFMA/TEGDMA）和 DS（DFMA/SR833s）。以基于 Bis - GMA 的 DRC（BT）作为对照。研究了双键转化率（DC）、细菌粘附、粘蛋白吸附、接触角、表面自由能、体积收缩率（VS）、收缩应力（SS）、吸水性（WS）和溶解度（SL）、水浸泡前后的弯曲强度（FS）和模量（FM），所有结果均采用方差分析（ANOVA 分析）进行统计分析。结果表明，DT 和 DS 具有相当的（ρ > 0.05）表面自由能，且低于 BT 的表面自由能（ρ < 0.05）。与 BT 相比，在相同表面粗糙度下（ρ > 0.05），DT 和 DS 表面积累的变形链球菌数量较少（ρ < 0.05）。在所有 DRCs 中，DS 因其高疏水性而具有最佳的抗粘蛋白吸附性能（ρ < 0.05）。与 BT 相比，两种基于 DFMA 的 DRCs 都具有诸如较低的 VS 和 SS（ρ < 0.05）、较低的 WS 和 SL（ρ < 0.05）以及更好的耐水性等优点。DS 具有抗菌粘附作用、抗粘蛋白吸附性能、最低的 VS 和 SL（ρ < 0.05），并且无论在水浸泡前后都具有最高的 FS 和 FM（ρ < 0.05），被认为在所有 DRCs 中具有最佳的综合性能。
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