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巨噬细胞在气道疾病中的作用——以猪繁殖与呼吸综合征病毒和抗氧化纳米颗粒治疗为重点。

The Role of Macrophages in Airway Disease Focusing on Porcine Reproductive and Respiratory Syndrome Virus and the Treatment with Antioxidant Nanoparticles.

机构信息

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.

Bundang New York Animal Hospital, Seongnam 13637, Republic of Korea.

出版信息

Viruses. 2024 Oct 1;16(10):1563. doi: 10.3390/v16101563.

DOI:10.3390/v16101563
PMID:39459897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11512392/
Abstract

Lung macrophage cells play a critical role in various lung diseases, and their state can change depending on the progression of the disease by inducing either an inflammatory or anti-inflammatory state. In this review, the potential therapeutic effects of treatment with antioxidant nanoparticles in air-borne diseases focusing on porcine reproductive and respiratory virus (PRRSV), considering reactive oxygen species (ROS) as one of the factors that regulate M1 and M2 macrophages in the inflammatory and anti-inflammatory states, respectively, was described. In addition, the author examines the status of protein structure research on CD163 (one of the markers of anti-inflammatory M2 macrophages) in human and veterinary lung diseases.

摘要

肺巨噬细胞在各种肺部疾病中发挥着关键作用，其状态可以根据疾病的进展而改变，诱导炎症或抗炎状态。在这篇综述中，考虑到活性氧 (ROS) 是分别调节炎症和抗炎状态下 M1 和 M2 巨噬细胞的因素之一，描述了针对猪繁殖与呼吸综合征病毒 (PRRSV) 等空气传播疾病，使用抗氧化纳米粒子治疗的潜在治疗效果。此外，作者还检查了人类和兽医肺部疾病中 CD163（抗炎 M2 巨噬细胞的标志物之一）的蛋白质结构研究现状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/e20d9c248a19/viruses-16-01563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/63906665619c/viruses-16-01563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/1bec0cf72f73/viruses-16-01563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/4b7e981e6197/viruses-16-01563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/e20d9c248a19/viruses-16-01563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/63906665619c/viruses-16-01563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/1bec0cf72f73/viruses-16-01563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/4b7e981e6197/viruses-16-01563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c27/11512392/e20d9c248a19/viruses-16-01563-g004.jpg

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本文引用的文献

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Viruses. 2023 Mar 17;15(3):773. doi: 10.3390/v15030773.
2
Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer.硫氧还蛋白-过氧化物酶IV轴在尿烷诱导的非小细胞肺癌中的关键作用
Antioxidants (Basel). 2023 Feb 3;12(2):367. doi: 10.3390/antiox12020367.
3
Genetic diversity of imported PRRSV-2 strains, 2005-2020, Hungary.
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Front Vet Sci. 2022 Oct 11;9:986850. doi: 10.3389/fvets.2022.986850. eCollection 2022.
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Tumor-Associated Macrophages and Ovarian Cancer: Implications for Therapy.肿瘤相关巨噬细胞与卵巢癌：对治疗的启示
Cancers (Basel). 2022 Apr 29;14(9):2220. doi: 10.3390/cancers14092220.
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Macrophage-Targeted Hydroxychloroquine Nanotherapeutics for Rheumatoid Arthritis Therapy.类风湿关节炎治疗的巨噬细胞靶向羟氯喹纳米治疗剂。
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