自然杀伤细胞及其代谢在 HIV-1 感染中的作用。
The Role of Natural Killer Cells and Their Metabolism in HIV-1 Infection.
机构信息
Department of Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany.
German Center for Infection Disease (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, 20251 Hamburg, Germany.
出版信息
Viruses. 2024 Oct 9;16(10):1584. doi: 10.3390/v16101584.
Natural killer (NK) cells are multifaceted innate effector cells that critically influence antiviral immunity, and several protective NK cell features that modulate HIV-1 acquisition and viral control have been described. Chronic HIV-1 infection leads to NK cell impairment that has been associated with metabolic dysregulations. Therapeutic approaches targeting cellular immune metabolism represent potential novel interventions to reverse defective NK cell function in people living with HIV.
自然杀伤 (NK) 细胞是多功能的先天效应细胞，对抗病毒免疫具有重要影响，已经描述了几种调节 HIV-1 获得和病毒控制的保护性 NK 细胞特征。慢性 HIV-1 感染导致 NK 细胞功能障碍，这与代谢失调有关。针对细胞免疫代谢的治疗方法代表了逆转 HIV 感染者缺陷 NK 细胞功能的潜在新干预措施。
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