Combining near-earth remote sensing spectral imaging technology with unmanned aerial vehicle (UAV) remote sensing sensing technology, we measured the Ningqi No. 10 goji variety under conditions of health, infestation by psyllids, and infestation by gall mites in Shizuishan City, Ningxia Hui Autonomous Region. The results indicate that the red and near-infrared spectral bands are particularly sensitive for detecting pest and disease conditions in goji. Using UAV-measured data, a remote sensing monitoring model for goji pest and disease was developed and validated using near-earth remote sensing hyperspectral data. A fully connected neural network achieved an accuracy of over 96.82% in classifying gall mite infestations, thereby enhancing the precision of pest and disease monitoring in goji. This demonstrates the reliability of UAV remote sensing. The pest and disease remote sensing monitoring model was used to visually present predictive results on hyperspectral images of goji, achieving data visualization.