Skjevrak I, Solheim E, Scheline R R
Xenobiotica. 1986 Jan;16(1):35-45. doi: 10.3109/00498258609043503.
The metabolism of 2',4',4-, 2',6',3- and 2',6',4-trihydroxydihydrochalcone was studied in rats. Approx. 25-35% of the oral dose (0.75 mmol/kg) was excreted in the urine during a five to six day period. The unchanged compounds were the most prominent urinary excretion products and were also present in large amounts in the faeces. Other metabolites of the three dihydrochalcones included minor amounts of hydroxylated products and subsequent O-methylated derivatives as well as minor amounts of degradation products (resorcinol and hydroxyphenylpropionic acids) arising from scission of the compounds by the normal gut microflora. The present results support the view that the degradative metabolism of dihydrochalcones involves scission leading to equal amounts of products derived from the A- and B-ring regions of these flavonoids.
在大鼠体内研究了2',4',4-、2',6',3-和2',6',4-三羟基二氢查耳酮的代谢情况。在五到六天的时间里，约25 - 35%的口服剂量（0.75 mmol/kg）经尿液排出。原形化合物是最主要的尿液排泄产物，在粪便中也大量存在。这三种二氢查耳酮的其他代谢产物包括少量的羟基化产物及其随后的O-甲基化衍生物，以及少量由正常肠道微生物群对化合物进行裂解产生的降解产物（间苯二酚和羟基苯丙酸）。目前的结果支持这样一种观点，即二氢查耳酮的降解代谢涉及裂解，导致从这些类黄酮的A环和B环区域衍生出等量的产物。
