Monge P, Solheim E, Scheline R R
Xenobiotica. 1984 Dec;14(12):917-24. doi: 10.3109/00498258409151490.
The metabolism of phloretin (2',4',6',4-tetrahydroxydihydrochalcone) was studied in rats. Approx. half of the intragastric dose (0.75 mmol/kg) was excreted in the urine, mainly within two days. Small initial amounts of phloretin were found, however most of the metabolites were degradation products. The latter included phloroglucinol and, in larger amounts, phloretic acid and related metabolites formed by its dehydrogenation, beta-oxidation and glycine conjugation. Phloroglucinol, administered in similar experiments, was rapidly (90% within 24 h) excreted in the urine, either unchanged or as conjugates (glucuronide/sulphate). Incubation of phloretin and its glucoside phloridzin with rat-caecal micro-organisms resulted in the formation of phloroglucinol and phloretic acid. The degradative pathways of metabolism of dihydrochalcones and other flavonoids are discussed.
在大鼠体内研究了根皮素（2'，4'，6'，4 - 四羟基二氢查耳酮）的代谢情况。大约一半的胃内给药剂量（0.75 mmol/kg）经尿液排出，主要在两天内排出。最初发现少量的根皮素，但大多数代谢产物是降解产物。后者包括间苯三酚，以及大量的根皮酸及其通过脱氢、β - 氧化和与甘氨酸结合形成的相关代谢产物。在类似实验中给予的间苯三酚迅速（24小时内90%）经尿液排出，要么未改变，要么以结合物（葡萄糖醛酸苷/硫酸盐）形式排出。根皮素及其糖苷根皮苷与大鼠盲肠微生物一起孵育会导致间苯三酚和根皮酸的形成。讨论了二氢查耳酮和其他黄酮类化合物的代谢降解途径。
