Obradovic Danko
University of Montenegro, Faculty of Science and Mathematics, Dzordza Vasingtona bb, 81000 Podgorica, Montenegro.
Arch Gerontol Geriatr. 2025 Feb;129:105665. doi: 10.1016/j.archger.2024.105665. Epub 2024 Oct 19.
This new theory of aging explains that aging and death due to aging are due to five factors, and also explains how these factors are interconnected and jointly lead to aging and death of the organism, pointing to many facts that strongly support it. The first factor is the harmful changes that occur in cellular structures. The second factor is the cessation of cell division in adult organisms, which leads to the inability to restore cellular structures. The third factor is the feature that cells do not die due to the accumulation of harmful changes that occur in the cells during the life of the organism. The fourth factor is the inability of stem cells to regenerate tissue by replacing such cells with new ones, because somatic cells do not die and there are no signals that stimulate the proliferation of stem cells and their differentiation into new ones that would replace dead cells. The fifth factor is that all cells die suddenly, due to the cessation of one of the vital functions of the organism, and not gradually during life, due to a decrease in the functionality of cells caused by the introduction of harmful changes in cellular structures, which would allow stem cells to regenerate tissues and keep the body young. Also, to show that this aging theory is valid, the theory gives its view of the evolution of five factors, which according to this theory lead to aging, which gives strong support to this theory.
这种新的衰老理论解释了衰老以及因衰老导致的死亡是由五个因素造成的，还解释了这些因素是如何相互关联并共同导致生物体衰老和死亡的，且指出了许多有力支持该理论的事实。第一个因素是细胞结构中发生的有害变化。第二个因素是成年生物体中细胞分裂的停止，这导致无法修复细胞结构。第三个因素是细胞不会因生物体生命过程中细胞内积累的有害变化而死亡的特性。第四个因素是干细胞无法通过用新细胞替代此类细胞来再生组织，因为体细胞不会死亡，且不存在刺激干细胞增殖及其分化为可替代死亡细胞的新细胞的信号。第五个因素是所有细胞会突然死亡，这是由于生物体一项重要功能的停止，而不是在生命过程中因细胞结构中引入有害变化导致细胞功能下降而逐渐死亡，若细胞功能下降，干细胞就能再生组织并使身体保持年轻。此外，为表明该衰老理论是正确的，该理论给出了对导致衰老的五个因素进化的观点，这为该理论提供了有力支持。
