Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-2909, USA.
The Buck Institute for Research on Aging, Novato, California 94945-1400, USA, and the Leibniz Institute on Aging-Fritz Lipmann Institute, Jena 07745, Germany.
Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18.
Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate, which is driven and maintained largely by tissue-resident somatic stem cell populations. Ageing is accompanied by a deregulation of stem cell function and a decline in regenerative capacity, often resulting in degenerative diseases. The identification of strategies to maintain stem cell function and regulation is therefore a promising avenue to allay a wide range of age-related diseases. Studies in various organisms have revealed a central role for metabolic pathways in the regulation of stem cell function. Ageing is associated with extensive metabolic changes, and interventions that influence cellular metabolism have long been recognized as robust lifespan-extending measures. In this Review, we discuss recent advances in our understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to homeostasis and ageing.
后生动物的许多组织和器官系统都具有内在的再生能力，这种能力主要由组织驻留的体干细胞群驱动和维持。衰老伴随着干细胞功能的失调和再生能力的下降，这常常导致退行性疾病。因此，寻找维持干细胞功能和调节的策略是缓解多种与年龄相关疾病的有希望的途径。在各种生物体中的研究揭示了代谢途径在干细胞功能调节中的核心作用。衰老与广泛的代谢变化有关，影响细胞代谢的干预措施长期以来一直被认为是延长寿命的有力措施。在这篇综述中，我们讨论了我们对干细胞功能的代谢控制的理解的最新进展，以及干细胞代谢与体内平衡和衰老的关系。
