Institute for Health and Bioeconomy (i4HB), NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica 2829-516, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica 2829-516, Portugal; CDG & Allies - Professionals and Patient Associations International Network (CDG & Allies - PPAIN), Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica 2829-516, Portugal.
Institute for Health and Bioeconomy (i4HB), NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica 2829-516, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica 2829-516, Portugal.
Semin Immunol. 2024 Jul-Sep;74-75:101900. doi: 10.1016/j.smim.2024.101900. Epub 2024 Oct 25.
Dendritic cells (DCs) are crucial for initiating immune responses against tumours by presenting antigens to T cells. Glycosylation, particularly sialylation, plays a significant role in regulating cell functions, by modulating protein folding and signalling. This review aimed to provide a comprehensive overview of how sialic acids influence key aspects of DC biology, including maturation, migration, antigen presentation, and T cell interactions. Sialic acids influence DC endocytosis, affecting their ability to uptake and present antigens, while guiding their migration to lymph nodes and inflamed tissues. Removing sialic acids enhances DC-mediated antigen presentation to T cells, potentially boosting immune responses. Additionally, sialylated glycans on DCs modulate immune checkpoints, which can impact tumour immunity. Hypersialylation of tumour mucins further promotes immune evasion by interacting with DCs. Understanding the interplay between sialylation and DC functions offers promising avenues for enhancing cancer immunotherapy.
树突状细胞（DCs）通过向 T 细胞呈递抗原，在启动针对肿瘤的免疫反应中起着至关重要的作用。糖基化，特别是唾液酸化，通过调节蛋白质折叠和信号转导，在调节细胞功能方面发挥着重要作用。本综述旨在全面概述唾液酸如何影响 DC 生物学的关键方面，包括成熟、迁移、抗原呈递和 T 细胞相互作用。唾液酸影响 DC 的内吞作用，影响其摄取和呈递抗原的能力，同时指导其向淋巴结和炎症组织迁移。去除唾液酸可增强 DC 介导的 T 细胞抗原呈递，从而潜在地增强免疫反应。此外，DC 上的唾液酸化糖链调节免疫检查点，这可能影响肿瘤免疫。肿瘤粘蛋白的高唾液酸化进一步通过与 DC 相互作用促进免疫逃逸。了解唾液酸化与 DC 功能之间的相互作用为增强癌症免疫治疗提供了有前途的途径。
