Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
Semin Immunol. 2024 Feb;71:101848. doi: 10.1016/j.smim.2023.101848. Epub 2023 Nov 29.
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major histocompatibility complex class I molecules for presentation to CD8 T cells. This process, called cross-presentation, is essential for initiating and regulating CD8 T cell responses against tumors and intracellular pathogens. In this review, we will discuss the role of DCs in cancer immunity, the molecular mechanisms underlying antigen cross-presentation by DCs, the immunosuppressive factors that limit the efficiency of this process in cancer, and approaches to overcome DC dysfunction and therapeutically promote antitumoral immunity.
树突状细胞（DCs）是专业的抗原呈递细胞，在塑造适应性免疫方面发挥着关键作用。DCs 具有独特的环境采样能力，能够捕获和处理外源性抗原，并将其加工成肽，然后加载到主要组织相容性复合体 I 类分子上，以供 CD8 T 细胞呈递。这个过程称为交叉呈递，对于启动和调节针对肿瘤和细胞内病原体的 CD8 T 细胞反应至关重要。在这篇综述中，我们将讨论 DCs 在癌症免疫中的作用、DCs 进行抗原交叉呈递的分子机制、限制该过程在癌症中效率的免疫抑制因子，以及克服 DC 功能障碍和治疗性促进抗肿瘤免疫的方法。
