School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Biotechnology & Food Science College, Tianjin University of Commerce, Tianjin 300134, China.
Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113426. doi: 10.1016/j.intimp.2024.113426. Epub 2024 Oct 29.
Diabetes mellitus, a chronic metabolic disorder, poses a significantly public health challenge. Extensive research highlights that contemporary dietary patterns, characterized by excessive intake of sugar, fat, and protein, are major contributors to the onset and progression of diabetes. The central element to this process is the aberrant activation of the advanced glycation end products (AGEs) - receptor for AGEs (RAGE) - oxidative stress axis, which plays a pivotal role in disrupting normal carbohydrate metabolism. This pathway presents a critical target for developing interventions aimed at mitigating diabetes and its complications. In recent years, natural polysaccharides have emerged as promising agents in the prevention and treatment of diabetes, due to their ability to inhibit AGE formation, regulate RAGE expression, and modulate the AGEs-RAGE-oxidative stress axis. In this paper, we explore the pathogenic mechanism of this axis and review the therapeutic potential of natural polysaccharides in managing diabetes and its complications. Our goal is to provide new insights for the effective management of diabetes and its associated health challenges.
糖尿病是一种慢性代谢性疾病，对公共健康构成了重大挑战。大量研究表明，现代饮食模式以过量摄入糖、脂肪和蛋白质为特征，是导致糖尿病发生和发展的主要因素。这一过程的核心环节是糖基化终产物（AGEs）-AGEs 受体（RAGE）-氧化应激轴的异常激活，该轴在破坏正常碳水化合物代谢中起着关键作用。该途径为开发旨在减轻糖尿病及其并发症的干预措施提供了一个关键靶点。近年来，天然多糖因其抑制 AGEs 形成、调节 RAGE 表达和调节 AGEs-RAGE-氧化应激轴的能力，成为预防和治疗糖尿病的有前途的药物。本文探讨了该轴的发病机制，并综述了天然多糖在治疗糖尿病及其并发症方面的治疗潜力。我们的目标是为有效管理糖尿病及其相关健康挑战提供新的见解。
