从不发生有丝分裂A相关激酶在内皮细胞中的新作用。
The emerging role of Never-in-Mitosis A - Related Kinases in the endothelium.
作者信息
Barabutis Nektarios, Fakir Saikat
机构信息
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
出版信息
Int J Biochem Cell Biol. 2024 Dec;177:106679. doi: 10.1016/j.biocel.2024.106679. Epub 2024 Oct 24.
Abstract
The endothelium forms a monolayer, which functions to ensure tissue homeostasis. Barrier hyperpermeability has been associated with lung, brain and eye disease. An emerging body of evidence reports the involvement of Never-in-Mitosis A - Related Kinases in vascular responses, suggesting their value as potential therapeutic targets in endothelial-dependent disorders.
摘要
内皮细胞形成一层单层结构，其功能是确保组织内环境稳定。屏障高通透性与肺部、脑部和眼部疾病有关。越来越多的证据表明，从不进行有丝分裂A相关激酶参与血管反应，这表明它们作为内皮依赖性疾病潜在治疗靶点的价值。
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