Reed W G, Anderson R J
Am Heart J. 1986 Jan;111(1):226-8. doi: 10.1016/0002-8703(86)90585-5.
The changes that occur in the cerebral circulation with chronic hypertension are important when considering the therapeutic possibilities in treating patients with severe hypertension. Care must be taken not to lower the blood pressure below the lower limit of autoregulation, no matter what drug is used. In patients with severe, chronic hypertension, blood pressure should be lowered carefully. Rapid blood pressure reduction to a level that is below the lower limit of autoregulation may result in central nervous system dysfunction due to cerebral hypoperfusion. This is especially true in patients with increased intracranial pressure and cerebral edema such as those with hypertensive encephalopathy.
在考虑重度高血压患者的治疗可能性时，慢性高血压引起的脑循环变化至关重要。无论使用何种药物，都必须注意不要将血压降至自动调节下限以下。对于重度慢性高血压患者，应谨慎降低血压。将血压迅速降至自动调节下限以下的水平可能会因脑灌注不足而导致中枢神经系统功能障碍。在颅内压升高和脑水肿的患者中，如高血压脑病患者，尤其如此。
