Oi K, Yamada Y
Nagasaki University, Japan.
Anesth Prog. 1990 Jan-Feb;37(1):24-8.
The purpose of this study was to examine effects on blood flow by alteration of blood pressure resulting from noxious stimuli. The experiment was carried out in anesthetized and paralyzed rabbits. Blood pressure was measured through a teflon catheter inserted in the common carotid artery (CCA). Blood flow at the CCA, internal carotid artery (ICA), or external carotid artery (ECA) was measured using an electromagnetic flowmeter placed at the CCA. The effects of pinching and electrical stimuli upon the blood pressure and flow were tested. Blood pressure at all three arteries decreased transiently from these noxious stimulations. There were no statistical changes in the blood flows respectively. However, different mechanism could exist between ECA and ICA because blood flow of ECA was decreased and that of ICA was increased or had no change. We concluded that vascular resistance reduction in the ICA against the arterial pressure decrement produced by noxious stimuli may be a control mechanism to keep cerebral blood flow constant. In contrast, there may be no such mechanism in the ECA circulation.
本研究的目的是探讨有害刺激引起的血压改变对血流的影响。实验在麻醉和麻痹的兔子身上进行。通过插入颈总动脉（CCA）的聚四氟乙烯导管测量血压。使用置于CCA处的电磁流量计测量CCA、颈内动脉（ICA）或颈外动脉（ECA）的血流。测试了夹捏和电刺激对血压和血流的影响。所有三条动脉的血压因这些有害刺激而短暂下降。血流分别没有统计学变化。然而，ECA和ICA之间可能存在不同机制，因为ECA的血流减少，而ICA的血流增加或没有变化。我们得出结论，ICA中针对有害刺激引起的动脉压下降的血管阻力降低可能是维持脑血流恒定的一种控制机制。相比之下，ECA循环中可能不存在这样的机制。
