Bahrampour Mina, Kochovska Slavica, Currow David C, Viney Rosalie, Mulhern Brendan
Centre for Health Economics Research and Evaluation (CHERE), University of Technology Sydney, Sydney, NSW, Australia.
Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia.
Qual Life Res. 2025 Feb;34(2):395-403. doi: 10.1007/s11136-024-03817-7. Epub 2024 Oct 26.
The EQ-5D has been used to assess health related quality of life (HRQoL) in respiratory conditions. However, the core descriptive system may not be sensitive to all the HRQoL impacts of these conditions. To increase the sensitivity of the descriptive system, two respiratory specific bolt-ons, have been developed. Psychometric assessment of the bolt-ons in comparison to other validated instruments is required to facilitate their use. Therefore, the aim of this study is to test the psychometric characteristics of the EQ-5D-5L + R using a large dataset collected in Australia.
A cross-sectional online survey was used to recruit adult respondents (≥ 18 years) representative of the Australian population. Descriptive and psychometric analyses were used to understand the performance of the EQ-5D-5L and bolt-ons in comparison to other validated instruments. The construct validity was estimated using correlations. Known-group validity was tested to determine the sensitivity of the instruments to differences across different severity groups.
Overall 10,033 respondents (52% female) completed the survey, of which 300 had a respiratory condition. There were moderate to high correlation between bolt-ons with EQ-5D-5L and WHODAS. The EQ-5D-5L + bolt-ons slightly reduced the ceiling effect in comparison to the EQ-5D-5L. The effect size was larger for people with respiratory conditions than people who did not have a respiratory condition.
The results show that adding the respiratory bolt-on to the EQ-5D-5L might slightly improve the instruments descriptive sensitivity. The choice of bolt-on may be driven by whether overall problems or limitations are being measured.
EQ-5D已被用于评估呼吸系统疾病中与健康相关的生活质量（HRQoL）。然而，核心描述系统可能对这些疾病的所有HRQoL影响不敏感。为了提高描述系统的敏感性，已开发了两个针对呼吸系统的附加模块。需要对这些附加模块与其他经过验证的工具进行心理测量评估，以促进其使用。因此，本研究的目的是使用在澳大利亚收集的大型数据集来测试EQ-5D-5L + R的心理测量特征。
采用横断面在线调查招募代表澳大利亚人口的成年受访者（≥18岁）。使用描述性和心理测量分析来了解EQ-5D-5L和附加模块与其他经过验证的工具相比的性能。使用相关性估计结构效度。测试已知组效度以确定工具对不同严重程度组之间差异的敏感性。
共有10,033名受访者（52%为女性）完成了调查，其中300人患有呼吸系统疾病。附加模块与EQ-5D-5L和世界卫生组织残疾评定量表（WHODAS）之间存在中度至高度相关性。与EQ-5D-5L相比，EQ-5D-5L +附加模块略微降低了天花板效应。患有呼吸系统疾病的人的效应量比没有呼吸系统疾病的人更大。
结果表明，在EQ-5D-5L中添加呼吸系统附加模块可能会略微提高工具的描述敏感性。附加模块的选择可能取决于测量的是总体问题还是局限性。
