Parmley W W, Chatterjee K
Am J Cardiol. 1986 Jan 31;57(3):34B-37B. doi: 10.1016/0002-9149(86)90996-3.
Arrhythmias are common in patients with congestive heart failure (CHF), especially those with concomitant ischemic heart disease. The degree of left ventricular dysfunction is the most important indicator of prognosis in patients with severe heart failure. In general, the better the patient's ventricular function, the greater his chance of survival. In addition, the severity of arrhythmias is also related to survival; patients with simple arrhythmias have higher survival rates than those with complex arrhythmias. All drugs used in the treatment of CHF have a potential proarrhythmic effect. In a study involving the new class of positive inotropic agents, a trend toward higher mortality was evident in CHF patients with ischemic heart disease compared with those with congestive dilated cardiomyopathy. A subgroup of patients also treated with antiarrhythmic agents had lower sudden death rates than those not receiving antiarrhythmics. A double-blind clinical trial of antiarrhythmic agents for patients with CHF is warranted.
心律失常在充血性心力衰竭（CHF）患者中很常见，尤其是那些伴有缺血性心脏病的患者。左心室功能障碍的程度是重度心力衰竭患者预后的最重要指标。一般来说，患者的心室功能越好，其存活几率就越大。此外，心律失常的严重程度也与生存率有关；单纯心律失常患者的生存率高于复杂心律失常患者。所有用于治疗CHF的药物都有潜在的促心律失常作用。在一项涉及新型正性肌力药物的研究中，与充血性扩张型心肌病患者相比，缺血性心脏病的CHF患者有更高的死亡率趋势。一组同时接受抗心律失常药物治疗的患者的猝死率低于未接受抗心律失常药物治疗的患者。有必要对CHF患者进行抗心律失常药物的双盲临床试验。
