Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia..
Acta Med Indones. 2024 Jul;56(3):400-408.
Monkeypox (Mpox) is a virus that originally infected only animals. Caused by the monkeypox virus, this infection presents with symptoms similar to smallpox. Although two years have passed since the 2022 outbreak, new cases continue to emerge monthly. Initially, human cases of mpox were confined to outbreaks in central and western Africa. However, the virus has recently spread globally, possibly due to a decline in vaccination rates. In this context, evidence for effective therapies, such as antivirals, is urgently needed. Three antivirals-tecovirimat, brincidofovir, and cidofovir-are known to have activity against the mpox virus. Their use is currently limited to expanded access for treating non-variola orthopoxvirus infections, with ongoing phase 3 trials. This review will discuss the mechanisms of action, clinical use, and efficacy of these antivirals.
猴痘（Mpox）是一种最初仅感染动物的病毒。由猴痘病毒引起，这种感染的症状与天花相似。尽管自 2022 年爆发以来已经过去了两年，但每月仍有新的病例出现。最初，人类的猴痘病例仅限于中非和西非的疫情爆发。然而，该病毒最近已在全球范围内传播，这可能是由于疫苗接种率下降所致。在这种情况下，迫切需要针对这种疾病的有效治疗方法，例如抗病毒药物。已知三种抗病毒药物——tecovirimat、brincidofovir 和 cidofovir——对猴痘病毒具有活性。它们的使用目前仅限于扩大用于治疗非天花正痘病毒感染的机会，同时正在进行 3 期临床试验。这篇综述将讨论这些抗病毒药物的作用机制、临床应用和疗效。
